What is the likely etiology of a 50-year-old female's complaint of burning pain in the thumb and index finger of her left hand, with nocturnal exacerbation and tingling upon carpal tunnel (median nerve) palpation, in the absence of trauma?

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Differential Diagnosis

  • Single Most Likely Diagnosis
    • D. Median nerve compression: The patient's symptoms of burning pain in the thumb and index finger, along with tingling in the hand when the carpal tunnel is tapped, are classic signs of median nerve compression, also known as carpal tunnel syndrome. The median nerve runs through the carpal tunnel and supplies sensation to the thumb, index, and middle fingers, as well as part of the ring finger.
  • Other Likely Diagnoses
    • A. Ulnar nerve compression: Although less likely, ulnar nerve compression could cause pain and tingling in the hand, particularly in the little and ring fingers. However, the patient's symptoms are more consistent with median nerve compression.
    • B. Scaphoid fracture: A scaphoid fracture could cause pain in the wrist and hand, but the patient denies trauma, making this diagnosis less likely. Additionally, scaphoid fractures typically cause pain on the radial side of the wrist.
  • Do Not Miss Diagnoses
    • Referred pain from cervical radiculopathy: Although less likely, it's essential to consider referred pain from cervical radiculopathy, as it could cause similar symptoms. Cervical radiculopathy can cause pain, numbness, and tingling in the arm and hand, and if missed, could lead to delayed diagnosis and treatment.
    • Thoracic outlet syndrome: This condition involves compression of the nerves and/or blood vessels that pass through the thoracic outlet, which could cause pain, numbness, and tingling in the arm and hand.
  • Rare Diagnoses
    • Radial neuropathy at the spiral groove (C): This condition is less likely, as it typically causes symptoms such as wrist drop or difficulty extending the wrist, which are not mentioned in the patient's symptoms.
    • Other rare conditions, such as tumors or infections, could also cause similar symptoms, but are less likely and would require further evaluation to diagnose.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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