What is the differential diagnosis for a 61-year-old female (YOF) with a chief complaint (CC) of lower abdominal (ABD) pain for 3 weeks, progressively worsening, with nausea, and a history of hysterectomy for adenocarcinoma of the uterus, currently undergoing chemotherapy, with known gallstones and tenderness in the lower abdominal quadrants?

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Differential Diagnosis for 61 YOF with Lower ABD Pain

  • Single Most Likely Diagnosis

    • Cholecystitis: Given the patient's recent CT scan showing gallstones and the presentation of progressive lower abdominal pain, nausea, and tenderness to palpation in the lower abdominal quadrants, cholecystitis is a highly plausible diagnosis. The presence of gallstones is a significant risk factor for developing cholecystitis.
  • Other Likely Diagnoses

    • Bowel Obstruction: The patient's history of abdominal surgery (hysterectomy) and current chemotherapy treatment increases the risk of bowel obstruction, which could present with abdominal pain, nausea, and tenderness.
    • Diverticulitis: The patient's age and symptoms of lower abdominal pain and tenderness could suggest diverticulitis, especially if there's a history of diverticular disease.
    • Chemotherapy-induced side effects: The patient's ongoing chemotherapy could be causing or exacerbating her abdominal symptoms, including pain and nausea.
  • Do Not Miss Diagnoses

    • Ovarian Cancer Recurrence: Although the patient had a hysterectomy, ovarian cancer can recur and present with abdominal pain and other non-specific symptoms. Given her history of adenocarcinoma of the uterus, it's crucial to consider the possibility of recurrence.
    • Perforated Viscus: A perforation in the gastrointestinal tract can lead to severe abdominal pain, tenderness, and potentially life-threatening complications if not promptly addressed.
    • Mesenteric Ischemia: This condition, involving insufficient blood flow to the intestines, can present with severe abdominal pain out of proportion to physical examination findings and is a medical emergency.
  • Rare Diagnoses

    • Neutropenic Colitis (Typhlitis): Given the patient's current chemotherapy treatment, which can cause neutropenia, there's a rare but possible risk of developing neutropenic colitis, characterized by inflammation of the cecum.
    • Abdominal Lymphoma: Although less common, lymphoma involving the abdomen could present with non-specific symptoms such as abdominal pain and nausea, especially in the context of a patient with a history of cancer.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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