From the Guidelines
Sporanox (itraconazole) can cause several skin disorders as side effects, including rash, pruritus, and urticaria, with rare but severe reactions such as Stevens-Johnson syndrome and toxic epidermal necrolysis 1. The most common skin reactions associated with Sporanox include:
- Rash
- Pruritus (itching)
- Urticaria (hives) In more severe cases, Sporanox may trigger serious skin reactions, though these are rare, including:
- Stevens-Johnson syndrome
- Toxic epidermal necrolysis
- Acute generalized exanthematous pustulosis Some patients may also experience photosensitivity reactions when exposed to sunlight while taking the medication, as well as skin discoloration or hyperhidrosis (excessive sweating) 1. These skin reactions occur because itraconazole can trigger immune-mediated hypersensitivity responses in some individuals, with the drug or its metabolites binding to proteins in the skin, creating antigens that the immune system recognizes as foreign, leading to inflammatory reactions. It is essential to seek medical attention immediately if any skin reaction develops while taking Sporanox, especially severe rash, blistering, or peeling, as these could indicate a serious adverse reaction requiring prompt discontinuation of the medication 1.
From the FDA Drug Label
Skin and Subcutaneous Tissue Disorders: Toxic epidermal necrolysis, Stevens-Johnson syndrome, acute generalized exanthematous pustulosis, erythema multiforme, exfoliative dermatitis, leukocytoclastic vasculitis, alopecia, photosensitivity, urticaria The skin disorders caused by Sporanox (Itraconazole) include:
- Toxic epidermal necrolysis
- Stevens-Johnson syndrome
- Acute generalized exanthematous pustulosis
- Erythema multiforme
- Exfoliative dermatitis
- Leukocytoclastic vasculitis
- Alopecia
- Photosensitivity
- Urticaria 2
From the Research
Skin Disorder Caused by Sporanox (Itraconazole)
- There are no research papers to assist in answering this question, as none of the provided studies 3, 4, 5, 6, 7 mention Sporanox (Itraconazole) as a cause of a skin disorder.
- The studies provided discuss Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) as severe cutaneous adverse reactions, but do not mention Itraconazole as a trigger.
- Some studies mention other medications, such as cephalosporins 3, ofloxacin 5, and fluconazole 6, as potential causes of SJS or TEN.
- However, without specific information on Itraconazole, it is not possible to determine the skin disorder caused by Sporanox (Itraconazole) based on the provided evidence.