Differential Diagnosis for Bullae Rash
- Single most likely diagnosis
- Pemphigus vulgaris: This is an autoimmune disease characterized by the formation of bullae (blisters) on the skin and mucous membranes. It is the most likely diagnosis due to the presence of bullae, which are a hallmark of the disease.
- Other Likely diagnoses
- Bullous pemphigoid: This is another autoimmune disease that causes bullae to form on the skin. It is similar to pemphigus vulgaris but tends to affect older adults and has a better prognosis.
- Dermatitis herpetiformis: This is a skin condition characterized by intensely itchy blisters that are often symmetrically distributed. It is associated with celiac disease and can be treated with a gluten-free diet.
- Epidermolysis bullosa: This is a group of genetic conditions that cause the skin to blister and tear easily. It can be inherited or acquired and has various subtypes.
- Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
- Stevens-Johnson syndrome: This is a rare but life-threatening condition that causes the skin to blister and peel, often in response to a medication or infection. It requires immediate medical attention to prevent serious complications.
- Toxic epidermal necrolysis: This is a severe skin condition that causes widespread skin necrosis and detachment, often in response to a medication. It has a high mortality rate and requires prompt treatment.
- Sepsis: In rare cases, a bullae rash can be a sign of sepsis, a life-threatening condition that occurs when the body's response to an infection becomes uncontrolled.
- Rare diagnoses
- Bullous lupus erythematosus: This is a rare subtype of lupus that causes bullae to form on the skin. It is often associated with other symptoms of lupus, such as joint pain and kidney disease.
- Linear IgA bullous dermatosis: This is a rare autoimmune disease that causes bullae to form on the skin, often in response to a medication or infection. It can be treated with immunosuppressive medications.