What are the differential diagnoses for arrhythmia (irregular heart rhythm)?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: March 3, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Differential Diagnosis for Arrhythmia

The following differential diagnosis is organized into categories to help guide the thought process and ensure that potentially life-threatening conditions are not missed.

  • Single Most Likely Diagnosis

    • Atrial Fibrillation: This is one of the most common arrhythmias, particularly in older adults, and can be caused by a variety of factors including hypertension, heart disease, and thyroid disorders. Its prevalence and the broad range of symptoms it can present make it a likely initial consideration.
  • Other Likely Diagnoses

    • Supraventricular Tachycardia (SVT): This includes conditions like atrioventricular nodal reentrant tachycardia (AVNRT) and atrioventricular reentrant tachycardia (AVRT), which are common and can present with palpitations, shortness of breath, and sometimes chest pain.
    • Ventricular Tachycardia (VT): Although less common than SVT, VT is a significant consideration, especially in patients with known heart disease, as it can lead to severe consequences if not promptly treated.
    • Sinus Tachycardia: Often a response to stress, dehydration, or other non-cardiac conditions, sinus tachycardia is common and usually benign but can be a symptom of an underlying issue that needs addressing.
  • Do Not Miss Diagnoses

    • Cardiac Tamponade: Although rare, cardiac tamponade can present with arrhythmias among other symptoms and is life-threatening if not promptly diagnosed and treated.
    • Pulmonary Embolism: Can cause arrhythmias, particularly sinus tachycardia, and is a medical emergency that requires immediate attention.
    • Myocardial Infarction: Arrhythmias can be a presenting feature of a heart attack, and missing this diagnosis can have fatal consequences.
    • Hyperkalemia/Hypokalemia: Electrolyte imbalances can cause various arrhythmias and are critical to identify and treat to prevent serious complications.
  • Rare Diagnoses

    • Brugada Syndrome: A genetic disorder that can lead to life-threatening arrhythmias, particularly VT, and often presents with a characteristic ECG pattern.
    • Long QT Syndrome: Another genetic condition that can cause VT and torsades de pointes, often triggered by certain medications or stress.
    • Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC): A rare heart condition that can lead to VT and sudden cardiac death, often in young individuals and athletes.
    • Wolff-Parkinson-White (WPW) Syndrome: A condition characterized by an accessory electrical pathway in the heart, leading to SVT, which can be life-threatening if not properly managed.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.