From the Guidelines
The brand name of Emtricitabine-Tenofovir combination is Truvada. This medication is a fixed-dose combination of two antiretroviral drugs used primarily for HIV prevention (as pre-exposure prophylaxis or PrEP) and HIV treatment, as indicated in the study published in Morbidity and Mortality Weekly Report 1. Truvada contains 200 mg of emtricitabine and 300 mg of tenofovir disoproxil fumarate in each tablet, typically taken once daily with or without food.
When used as PrEP, it can reduce the risk of HIV infection by more than 90% when taken consistently. The iPrEx study, a multinational, randomized, double-blind, placebo-controlled, phase III clinical trial, demonstrated that TDF plus FTC taken orally once a day as preexposure prophylaxis (PrEP) is safe and partially effective in reducing HIV acquisition among MSM when provided with regular monitoring of HIV status and ongoing risk-reduction and PrEP medication adherence counseling 1.
For HIV treatment, Truvada is usually combined with other antiretroviral medications as part of a complete regimen. The medication works by inhibiting HIV reverse transcriptase, preventing the virus from replicating in the body. Patients should be aware that Truvada requires regular kidney function monitoring as tenofovir can cause renal issues in some individuals. Key points to consider when prescribing Truvada include:
- Regular monitoring of HIV status
- Ongoing risk-reduction and PrEP medication adherence counseling
- Regular kidney function monitoring
- Potential for renal issues in some individuals
It is essential to note that while Truvada is effective in reducing the risk of HIV infection, it is not a substitute for other prevention methods, such as condom use and regular HIV testing. Additionally, there is a newer formulation called Descovy (emtricitabine-tenofovir alafenamide) which has a better renal and bone safety profile but is not approved for PrEP use in people at risk from receptive vaginal sex.
From the FDA Drug Label
Emtricitabine and tenofovir disoproxil fumarate tablets are fixed-dose combination tablets containing emtricitabine (FTC) and tenofovir disoproxil fumarate (TDF) The brand name of Emtricitabine (Emtricitabine) - Tenofovir (Tenofovir) combination is not explicitly stated in the provided drug labels [2] [3].
From the Research
Emtricitabine-Tenofovir Combination
The brand name of the Emtricitabine-Tenofovir combination is:
Key Components
The combination consists of:
Usage
Truvada is used for: