What is the choice of treatment for Hafnia alvei bacteremia?

From the Research

Treatment of Hafnia alvei Bacteremia

The choice of treatment for Hafnia alvei bacteremia depends on various factors, including the severity of the infection, the patient's underlying health conditions, and the susceptibility of the bacteria to antibiotics.

• Antibiotic treatment options include:
  • Cefepime, as used in patients with Hafnia alvei-induced urosepsis 1, 2
  • Netilmicin and Imipenem, which were successful in treating two patients with nosocomial infections 3
  • Ciprofloxacin, which was used to treat a patient with Hafnia alvei pyelonephritis and urosepsis 2
• The susceptibility of Hafnia alvei to various antibiotics has been reported in several studies, including:
  • 100% susceptibility to netilmicin, ciprofloxacin, and imipenem 4
  • 92% susceptibility to piperacillin 4
  • 90% susceptibility to co-trimoxazole 4
  • 88% susceptibility to ceftriaxone and ceftazidime 4
• It is essential to note that Hafnia alvei can produce inducible Bush group 1 beta-lactamase, which may contribute to antibiotic resistance 1
• In some cases, the source of bacteremia may be associated with central venous catheters, and removal of the catheter may be necessary as part of the treatment 5