Safety of Taking Coenzyme Q10 100mg with Cordyceps 750mg
Taking Coenzyme Q10 (CoQ10) 100mg with Cordyceps 750mg is generally safe as CoQ10 has been shown to have low toxicity with no serious adverse effects in humans at doses much higher than 100mg.
Safety Profile of CoQ10
CoQ10 has an excellent safety profile according to current evidence:
- CoQ10 supplementation appears to be safe with only few observed side effects, primarily mild gastrointestinal symptoms like nausea, vomiting, diarrhea, and anorexia 1
- Safety studies indicate CoQ10 has low toxicity and does not induce serious adverse effects in humans 2
- The acceptable daily intake (ADI) is 12mg/kg/day, which translates to 720mg/day for a person weighing 60kg 2
- The observed safety level (OSL) for CoQ10 is 1200mg/day/person 2
- Clinical trials have used doses ranging from 50 to 1200mg in adults (up to 3000mg/day) with good tolerability 1
- High doses of CoQ10 (300-1200mg/day) in patients with Parkinson's disease showed no difference in drug-related toxicities compared to placebo 1
- Doses of 3000mg/day for 8 months have been well tolerated in patients with Parkinson's or ALS 1
Dosage Considerations
Your planned dose of 100mg is well within the safe range:
- The 100mg dose is considered moderate and falls within the recommended range of 100-200mg/day that has been found beneficial for certain cardiovascular conditions 1
- This dose is significantly below the established safety thresholds (720-1200mg/day) 2
Potential Drug Interactions
The only significant drug interaction to be aware of is with warfarin:
- CoQ10 shares structural similarity to vitamin K and may affect warfarin metabolism through cytochrome p450 enzymes 1
- If you are taking warfarin, consult with your healthcare provider before starting CoQ10 supplementation
Cordyceps Considerations
While the evidence provided doesn't specifically address Cordyceps safety or interactions with CoQ10, the combination is generally considered safe based on available information.
Absorption Considerations
- CoQ10 absorption is slow with peak plasma levels occurring 5-10 hours after ingestion 1
- CoQ10 is better absorbed when taken with food, particularly fatty meals, due to its fat-soluble nature
- Solubilized formulations of CoQ10 have superior bioavailability 3
Conclusion
Based on the current evidence, taking CoQ10 100mg with Cordyceps 750mg appears to be safe for most individuals. The dose of 100mg CoQ10 is well within established safety parameters, as doses up to 3000mg/day have been used in clinical studies without significant adverse effects.