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Differential Diagnosis for Unilateral Pink Eye and Hard Cervical Lymph Node

Single Most Likely Diagnosis

  • Viral Conjunctivitis with Reactive Lymphadenitis: This is the most common cause of unilateral pink eye, often accompanied by a hard cervical lymph node due to the body's immune response to the viral infection.

Other Likely Diagnoses

  • Bacterial Conjunctivitis: Similar to viral conjunctivitis but typically presents with more purulent discharge and may require antibiotic treatment. The hard cervical lymph node could be reactive to the bacterial infection.
  • Allergic Conjunctivitis: Seasonal or perennial allergies can cause unilateral or bilateral pink eye, and a hard cervical lymph node could be part of an allergic reaction, though this is less common.
  • Chlamydial Conjunctivitis: Caused by Chlamydia trachomatis, this form of conjunctivitis can present with unilateral pink eye and lymphadenopathy, particularly in adults.

Do Not Miss Diagnoses

  • Lymphoma: Although rare, lymphoma can present with hard cervical lymphadenopathy and, in some cases, may involve the eye, causing conjunctivitis or other ocular symptoms.
  • Tuberculosis: TB can cause conjunctivitis and lymphadenitis, especially in endemic areas or in immunocompromised patients. It's crucial to consider TB due to its public health implications and the need for specific treatment.
  • Syphilis: In its secondary stage, syphilis can cause a wide range of symptoms, including conjunctivitis and lymphadenopathy. Given the potential for severe complications if left untreated, syphilis should not be missed.

Rare Diagnoses

  • Kawasaki Disease: Although more commonly seen in children, Kawasaki disease can cause conjunctivitis and lymphadenopathy among its myriad symptoms. It's a rare but important consideration due to its potential for cardiac complications.
  • Sarcoidosis: This autoimmune disease can affect multiple parts of the body, including the eyes (causing uveitis or conjunctivitis) and lymph nodes. While rare, sarcoidosis is an important differential due to its systemic implications.
  • Cat-Scratch Disease: Caused by Bartonella henselae, this disease can lead to conjunctivitis (typically with a distinctive cat scratch or exposure history) and regional lymphadenopathy, including hard cervical lymph nodes.

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Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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