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Differential Diagnosis for Diffuse Lymphadenopathy, Refractory Hypertension, and Clotting Abnormalities

Single Most Likely Diagnosis

  • Lymphoma: This is a common cause of diffuse lymphadenopathy and can also lead to refractory hypertension due to renal involvement or compression. Clotting abnormalities can occur due to paraneoplastic syndromes or direct marrow involvement affecting coagulation factor production.

Other Likely Diagnoses

  • Chronic Lymphocytic Leukemia (CLL): CLL can cause lymphadenopathy and may lead to secondary hypertension. Clotting issues can arise from the disease itself or its treatment.
  • Rheumatologic Diseases (e.g., Lupus, Rheumatoid Arthritis): These conditions can cause lymphadenopathy, hypertension (due to renal involvement), and clotting abnormalities (such as antiphospholipid syndrome in lupus).
  • Infectious Diseases (e.g., Tuberculosis, HIV): Certain infections can lead to diffuse lymphadenopathy and may also cause hypertension and clotting issues through various mechanisms, including direct organ involvement or secondary to inflammation.

Do Not Miss Diagnoses

  • Cancer with Metastasis: Metastatic cancer can cause diffuse lymphadenopathy and may lead to hypertension and clotting abnormalities through mechanisms like renal metastasis or paraneoplastic syndromes.
  • Thrombotic Thrombocytopenic Purpura (TTP): Although rare, TTP can cause clotting abnormalities and may present with hypertension. Lymphadenopathy is less common but can occur.
  • Histiocytosis: This group of diseases can cause lymphadenopathy and systemic symptoms, including hypertension and clotting issues, especially if there's multi-organ involvement.

Rare Diagnoses

  • Castleman Disease: A rare disorder that can cause lymphadenopathy and may be associated with systemic symptoms, including clotting abnormalities and potentially hypertension.
  • Kikuchi-Fujimoto Disease: A rare form of lymphadenitis that can cause lymphadenopathy and may occasionally be associated with systemic symptoms, including clotting issues.
  • Amyloidosis: Can cause lymphadenopathy, hypertension (through renal involvement), and clotting abnormalities, though it's a less common diagnosis for these symptoms collectively.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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