Differential Diagnosis for Hyperphagia in a Young Woman
Single Most Likely Diagnosis
- Bulimia Nervosa: This eating disorder is characterized by episodes of binge eating (hyperphagia) followed by compensatory behaviors such as self-induced vomiting, laxatives, or excessive exercise. It is common in young women and aligns closely with the symptom of hyperphagia.
Other Likely Diagnoses
- Binge Eating Disorder: Similar to bulimia nervosa but without the compensatory behaviors, leading to potential weight gain and other metabolic issues.
- Polycystic Ovary Syndrome (PCOS): While not exclusively causing hyperphagia, PCOS can lead to increased hunger and food cravings due to insulin resistance and hormonal imbalances.
- Hypothyroidism: Can cause increased appetite and weight gain due to a decrease in metabolic rate.
Do Not Miss Diagnoses
- Diabetes Mellitus: Especially type 1 or uncontrolled type 2, can cause polyphagia (increased hunger) due to high blood glucose levels and the body's inability to utilize glucose for energy.
- Pituitary Tumors (e.g., Craniopharyngioma): Rare tumors that can affect hunger and satiety centers in the brain, leading to hyperphagia.
- Prader-Willi Syndrome: A genetic disorder that can cause severe hyperphagia, among other symptoms, due to hypothalamic dysfunction.
Rare Diagnoses
- Kleine-Levin Syndrome: A rare neurological disorder characterized by recurring periods of excessive daytime sleepiness and automatic behavior, including hyperphagia.
- Leptin Deficiency: A very rare condition where the body does not produce enough leptin, a hormone that helps regulate energy balance by inhibiting hunger.
- Ghrelinoma: A rare tumor that secretes ghrelin, a hormone that stimulates appetite, leading to hyperphagia.