What is the preferred time to take Myrbetriq (mirabegron)?

Preferred Time to Take Myrbetriq (Mirabegron)

Myrbetriq can be taken at any time of day, but it should be taken consistently at the same time each day with or without food. While food affects the absorption of mirabegron, this does not warrant specific timing adjustments in clinical practice.

Timing Considerations

Effect of Food on Absorption

• Food intake reduces the plasma concentration (Cmax) of mirabegron:
  • High-fat breakfast reduces Cmax by approximately 45% and AUC by 17% 1
  • Low-fat breakfast reduces Cmax by approximately 75% and AUC by 51% 1
  • Despite these reductions, dose adjustment based on food intake is not considered necessary for clinical efficacy 1

Practical Recommendations

• Consistency is key: Take Myrbetriq at the same time each day to maintain steady blood levels
• If experiencing gastrointestinal side effects, taking with food may help mitigate these effects
• For patients who have trouble remembering to take medications, linking administration to a daily routine (morning or evening) can improve adherence

Formulation Considerations

Extended-Release Tablets

• Myrbetriq is formulated as an extended-release tablet using oral controlled-absorption system (OCAS) technology 1
• This formulation is designed to provide consistent drug release over 24 hours, supporting once-daily dosing
• The extended-release properties are maintained regardless of administration time

Special Populations

• For pediatric patients weighing ≥35 kg, the extended-release tablets can be used 2
• For pediatric patients weighing <35 kg, only the extended-release oral suspension should be used 2

Clinical Efficacy Considerations

• In clinical trials, mirabegron demonstrated significant improvements in overactive bladder symptoms with once-daily dosing 3, 4
• Efficacy was maintained throughout the 24-hour period between doses
• Significant improvements in micturition frequency, urgency incontinence, and mean volume voided were observed as early as week 4 and maintained throughout treatment 4

Common Pitfalls to Avoid

1. Inconsistent timing: Varying the time of administration may lead to fluctuations in drug levels
2. Missing doses: If a dose is missed, take it as soon as remembered, but do not take two doses at the same time
3. Substituting formulations: The extended-release tablet and extended-release oral suspension are not substitutable on a mg-by-mg basis 2
4. Abrupt discontinuation: Consult healthcare provider before stopping the medication

While the time of day for taking Myrbetriq is flexible, maintaining consistency in administration timing is important for optimal therapeutic effect. The medication can be taken with or without food, though food does affect absorption to some degree.