How do you code for cryotherapy of multiple warts at one time?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: July 25, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Coding for Cryotherapy of Multiple Warts

When treating multiple warts with cryotherapy at the same visit, you should code each wart location separately using the appropriate CPT codes for destruction of benign lesions.

Coding Guidelines for Cryotherapy of Multiple Warts

CPT Code Selection

  • Use CPT codes 17110 or 17111 depending on the number of warts treated:
    • 17110: Destruction of benign lesions (e.g., warts) other than skin tags or cutaneous vascular lesions; up to 14 lesions
    • 17111: Destruction of benign lesions; 15 or more lesions

Documentation Requirements

  • Document the following in the medical record:
    • Total number of warts treated
    • Anatomic location of each wart
    • Size of each wart
    • Method of destruction (cryotherapy with liquid nitrogen)
    • Duration of freeze time for each wart

Treatment Approach

When treating multiple warts with cryotherapy, follow these evidence-based guidelines:

  1. Freeze time: Apply liquid nitrogen until an ice-ball formation has spread from the center to include a margin of 2 mm around each wart 1

    • For better efficacy, consider a sustained 10-second freeze which has been shown to be more effective than traditional shorter freezes 2
  2. Application method: Either spray or cotton wool bud application is equally effective 1

    • Spray technique is often more convenient for multiple warts
    • Cotton wool bud may allow more precise application in sensitive areas
  3. Treatment intervals: Schedule follow-up treatments every 1-2 weeks 3

    • Research suggests that shorter intervals (2 weeks) with moderate freeze time may be more effective than longer intervals with extended freeze time 4

Special Considerations for Different Anatomic Sites

Different anatomic locations may require modified approaches:

  • Plantar warts: Consider paring the wart before treatment and using a double freeze-thaw cycle 1
  • Vaginal warts: Use caution with cryotherapy; avoid using a cryoprobe due to risk of perforation 3
  • Urethral meatus warts: Use precise application to avoid damage to surrounding tissue 3
  • Anal warts: May require consultation with a specialist, especially for intra-anal warts 3

Billing Pitfalls to Avoid

  1. Don't unbundle codes: Do not report individual lesion destruction separately when they should be reported under a single code
  2. Don't double-code: Avoid using both 17110 and 17111 for the same session
  3. Modifier usage: Use appropriate modifiers if treating warts on different anatomic sites that require different approaches
  4. Documentation: Ensure thorough documentation of medical necessity for treating multiple warts

Treatment Efficacy Considerations

The cure rate for cryotherapy of warts varies based on several factors:

  • Duration of wart presence: Warts present for less than 6 months have significantly higher clearance rates (84%) compared to those present longer than 6 months (39%) 1
  • Number of warts: Patients with fewer warts generally have better outcomes 4
  • Treatment protocol: A 10-second sustained freeze has shown 64% clearance compared to 39% with traditional shorter freezes, though with increased discomfort 2

For patients with multiple or resistant warts, consider alternative or combination therapies if cryotherapy fails after 3-6 treatments 3.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.