Can Entresto (Sacubitril/Valsartan) be taken with Losartan?

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From the Research

Entresto (Sacubitril/Valsartan) and Losartan Interaction

  • There is no direct evidence in the provided studies that specifically addresses the interaction between Entresto (Sacubitril/Valsartan) and Losartan.
  • However, it is known that both Entresto and Losartan are used to treat heart failure and high blood pressure, and they work by targeting similar pathways in the body 1, 2.
  • A study compared the efficacy and safety of Sacubitril/Valsartan to Valsartan in patients with heart failure, and found that Sacubitril/Valsartan was superior to Valsartan in some outcomes, but had a higher risk of hypotension 1.
  • Another study found that Sacubitril/Valsartan did not reduce the risk of atrial fibrillation compared to ACEIs/ARBs, which includes Losartan 2.
  • There is evidence that Entresto can be used in combination with other medications, such as metoprolol succinate, to improve cardiac function and reduce coagulation function in patients with congestive heart failure 3.
  • Additionally, a study found that the use of SGLT2 inhibitors or ARNI (including Entresto) was associated with a lower risk of atherosclerotic cardiovascular disease in patients with coexisting diabetes and heart failure 4.

Potential Considerations

  • When considering the use of Entresto with Losartan, it is essential to monitor blood pressure and adjust the dosage as needed to minimize the risk of hypotension 1.
  • Patients should be closely monitored for signs of hypotension, hyperkalemia, and worsening renal function when using Entresto with other medications, including Losartan 1, 3.
  • The combination of Entresto and Losartan may be beneficial in reducing the risk of cardiovascular disease in patients with heart failure and diabetes, but more research is needed to confirm this 4.

References

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Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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