From the FDA Drug Label
Rosuvastatin calcium, USP is a white to almost white amorphous powder that is sparingly soluble in water and methanol, and slightly soluble in ethanol. The chemical name for rosuvastatin calcium, USP is bis[(E)-7-4-(4-fluorophenyl)-6-isopropyl-2 [methyl(methylsulfonyl)amino]pyrimidin-5-yl-3,5-dihydroxyhept-6-enoic acid] calcium salt Each tablet contains: crospovidone, dibasic calcium phosphate dihydrate, hypromellose, lactose monohydrate, magnesium stearate, microcrystalline cellulose, red ferric oxide, triacetin and titanium dioxide.
The interaction between Rosuvastatin and calcium is that calcium is a component of the rosuvastatin calcium salt. Rosuvastatin is administered as a calcium salt, and it also contains dibasic calcium phosphate dihydrate as an inactive ingredient. However, there is no information in the drug labels about a significant interaction between rosuvastatin and calcium that would affect the efficacy or increase the risk of side effects of rosuvastatin 1 1.
From the Research
Rosuvastatin can be safely taken with calcium supplements, but it's best to separate them by at least 2 hours to avoid potential interactions. Calcium supplements may slightly decrease the absorption of rosuvastatin, reducing its effectiveness in lowering cholesterol. If you're taking both medications, consider taking rosuvastatin in the evening (its recommended timing for optimal effect) and calcium supplements in the morning with food. This separation helps ensure that both medications work properly. Rosuvastatin works by inhibiting an enzyme involved in cholesterol production in the liver, while calcium supplements provide essential minerals for bone health.
Some key points to consider when taking rosuvastatin with calcium supplements include:
- Rosuvastatin has a unique pharmacologic and pharmacokinetic profile, with a high affinity for the active site of the HMG-CoA reductase enzyme 2
- The medication has been shown to be effective in reducing LDL cholesterol and increasing HDL cholesterol levels, with a low potential for cytochrome P450 drug interactions 3, 4
- However, calcium supplements may interact with rosuvastatin by decreasing its absorption, and therefore, it is recommended to separate the two medications by at least 2 hours 5
- Rosuvastatin has been associated with adverse effects such as myopathy, rhabdomyolysis, and renal failure, and its co-administration with certain drugs may increase the risk of toxicity 5
If you experience any unusual side effects when taking these medications together, such as increased muscle pain or digestive issues, consult your healthcare provider. They may recommend adjusting your dosing schedule or monitoring your cholesterol levels more closely to ensure the rosuvastatin remains effective. It is essential to weigh the benefits and risks of taking rosuvastatin with calcium supplements and to consult with a healthcare provider to determine the best course of treatment.