From the Research
Mirena (levonorgestrel) is not specifically designed to address elevated DHEA levels in Polycystic Ovary Syndrome (PCOS) and should not be used as a primary treatment for this condition. Mirena works primarily by releasing a small amount of progestin locally in the uterus, which can help regulate menstrual bleeding and provide contraception [ 1 ]. For women with PCOS who experience irregular or heavy periods, Mirena can be beneficial by thinning the uterine lining and potentially reducing menstrual flow. However, Mirena does not directly affect adrenal hormone production, including DHEA, which is often elevated in some PCOS patients [ 2 ].
Some key points to consider:
- Elevated DHEA levels are a common feature of PCOS, particularly in non-classic (B or C) phenotypes [ 2 ]
- Mirena may help manage some symptoms of PCOS, such as irregular menstrual bleeding, but it is not a treatment for elevated DHEA levels [ 1 ]
- Other treatments, such as lifestyle modifications (weight loss, regular exercise), anti-androgen medications, or specific endocrine treatments, may be more effective in addressing elevated DHEA levels [ 3 ]
- A comprehensive treatment plan that addresses hormonal imbalances, including elevated DHEA levels, should be developed in consultation with an endocrinologist or gynecologist who specializes in PCOS [ 1 ]
In terms of treatment options, the most recent and highest quality study [ 1 ] suggests that anti-androgens may be effective in treating hirsutism in PCOS, but their use should be considered on a case-by-case basis, taking into account individual risk factors and characteristics. Additionally, combination treatment with anti-androgens and metformin may result in lower testosterone levels compared to metformin alone [ 1 ]. However, Mirena is not a primary treatment for elevated DHEA levels, and its use should be limited to managing menstrual symptoms in women with PCOS.