From the FDA Drug Label
The recommended dose of cefixime is 400 mg daily. For the treatment of uncomplicated cervical/urethral gonococcal infections, a single oral dose of 400 mg is recommended.
The recommended dose of suppressive antibiotics with cefixime is 400 mg daily.
- The dose for uncomplicated gonococcal infections is a single oral dose of 400 mg. There is no specific information on suppressive antibiotic use, so this answer is based on the standard dosing recommendations for cefixime 1.
From the Research
For suppressive antibiotic therapy with cefixime, the recommended dose is typically 400 mg once daily. This regimen is appropriate for long-term suppression of recurrent urinary tract infections or other chronic infections requiring ongoing antibiotic coverage. The 400 mg daily dose provides adequate serum and tissue concentrations to inhibit bacterial growth while minimizing the risk of developing resistance.
Key Considerations
- Before starting suppressive therapy, it's essential to confirm the susceptibility of the causative organism to cefixime through appropriate cultures 2.
- Patients should be monitored regularly for adverse effects such as gastrointestinal disturbances, allergic reactions, and the development of resistant organisms 3.
- Periodic urine cultures (every 3-6 months) are recommended to assess continued effectiveness.
- Suppressive therapy should be reassessed every 6-12 months to determine if continued treatment is necessary.
Mechanism of Action
Cefixime works by inhibiting bacterial cell wall synthesis, and its once-daily dosing improves compliance compared to more frequently dosed antibiotics 4.
Efficacy and Safety
Studies have shown that cefixime is effective in treating urinary tract infections, with a clinical effectiveness rate of 94-96% 5. The safety profile of cefixime is favorable, with few adverse effects reported, such as diarrhea and stool changes 6.