Bimatoprost vs Latanoprost for Eyelash Growth
Bimatoprost is more effective than latanoprost for promoting eyelash growth, with stronger evidence supporting its use for this specific purpose. 1, 2
Comparative Efficacy
Bimatoprost
- FDA-approved specifically for eyelash hypotrichosis (inadequate eyelashes) as Latisse® (0.03% solution) 3, 4
- In a multicenter, randomized, double-masked, vehicle-controlled study, 78.1% of subjects using bimatoprost demonstrated at least a 1-grade increase in eyelash prominence after 16 weeks 2
- Produces measurable increases in:
Latanoprost
- Not FDA-approved specifically for eyelash growth
- Shows more modest effects on eyelash growth compared to bimatoprost
- In a quantitative analysis, latanoprost increased eyelash length from 5.8mm to 6.6mm (0.8mm increase) after 10 weeks of treatment 6
- Less consistent results for cosmetic eyelash enhancement 7
Mechanism of Action
Both medications are prostaglandin F2α analogs that work by:
- Stimulating resting hair follicles (telogen phase) to enter the growth phase (anagen phase)
- Prolonging the anagen phase, resulting in longer eyelashes 4
- Increasing melanin content in eyelashes, making them appear darker 8
Safety Profile
Bimatoprost
- Most common side effect is conjunctival hyperemia (45% of users) 3
- Other potential side effects include:
Latanoprost
- Generally similar side effect profile to bimatoprost but with:
Application Method
For optimal eyelash growth:
- Apply once daily to the upper eyelid margin at the base of the eyelashes
- Remove contact lenses before application (can be reinserted 15 minutes after with latanoprost) 8
- Consistent application is necessary for continued results
- Effects are reversible upon discontinuation for eyelash characteristics, but iris color changes may be permanent 3, 8
Important Considerations
- Both medications were originally developed for glaucoma treatment and lower intraocular pressure 1
- Monitor for intraocular pressure changes, especially in patients with risk factors for glaucoma 7
- Avoid allowing the applicator tip to contact the eye to prevent contamination 8
- Effects on eyelash growth are typically noticeable within 8-16 weeks of consistent use 2, 5
- Discontinuation leads to gradual return to baseline eyelash characteristics within weeks to months 8
Conclusion
For patients specifically seeking eyelash enhancement, bimatoprost 0.03% provides superior results compared to latanoprost, with more substantial increases in eyelash length, thickness, and darkness. However, patients should be informed about potential side effects, particularly the risk of permanent iris color change and periorbital skin darkening.