From the Guidelines
NPH insulin is available under several brand names, including Humulin N, Novolin N, and Insulatard. These intermediate-acting insulins typically begin working within 1-2 hours after injection, peak in 4-12 hours, and last for about 12-18 hours [ 1 ]. NPH insulin appears cloudy because it contains protamine, which slows absorption. Patients using NPH insulin typically inject it once or twice daily, often before breakfast and dinner, to provide basal insulin coverage.
Key Characteristics of NPH Insulin
- Begins working within 1-2 hours after injection
- Peaks in 4-12 hours
- Lasts for about 12-18 hours
- Contains protamine, which slows absorption
- Typically injected once or twice daily The standard starting dose is often 0.1-0.2 units per kilogram of body weight per day, but this must be individualized based on blood glucose monitoring results [ 1 ]. NPH insulin should be gently rolled (not shaken) before administration to ensure proper mixing of the suspension.
Administration and Monitoring
- Standard starting dose: 0.1-0.2 units per kilogram of body weight per day
- Individualized based on blood glucose monitoring results
- Gently rolled (not shaken) before administration It's essential to consider the cost and potential for hypoglycemia when selecting an insulin product, particularly for patients who may require substantial doses [ 1 ].
From the Research
Brand Names of Neutral Protamine Hagedorn (NPH) Insulin
- Novolin NPH [ 2, 3 ]
- Humulin NPH [ no reference ]
- NovoLog Mix 70/30, contains 70% NPH insulin [ 4, 5 ]