What is the price of biofiller (biocompatible filler) treatment?

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Bio Filler Pricing: Cost-Effective Alternative to Traditional Fillers

Bio filler (autologous platelet-rich plasma gel) is a cost-effective aesthetic treatment option, with prices significantly lower than traditional hyaluronic acid fillers, typically costing around $92-119 per single treatment session. 1

What is Bio Filler?

Bio filler (also called Alb-PRF or autologous platelet concentrates) is an injectable treatment made from the patient's own blood components:

  • Created by processing the patient's blood through centrifugation
  • The platelet-poor plasma (PPP) is heated to create albumin gel
  • This gel is mixed with liquid platelet-rich fibrin (PRF) to create an injectable filler
  • Completely autologous (from patient's own body), reducing risk of allergic reactions

Cost Breakdown

The cost advantage of bio filler comes from its autologous nature and relatively simple preparation process:

  • Single bio filler treatment: approximately $92-119 1, 2
  • Cost components include:
    • Equipment use (centrifuge, heating apparatus)
    • Consumables (syringes, needles, dressings)
    • Nursing/practitioner time
    • Facility fees

Cost Comparison with Other Treatments

Bio filler is generally more cost-effective than traditional fillers:

Treatment Approximate Cost Notes
Bio Filler $92-119 per session Typically requires 2-3 sessions initially [1]
Hyaluronic Acid Fillers $500-800+ per syringe Often requires multiple syringes [3]
Cryotherapy $145 total treatment cost For comparison of aesthetic procedures [2]
Topical 5-fluorouracil $171 total treatment cost For comparison of aesthetic procedures [1]

Duration and Value Considerations

The value proposition of bio filler includes:

  • Duration of effects: 4-6 months before resorption 1
  • Safety profile: Lower risk of complications compared to permanent fillers 4, 3
  • Natural results: Well-accepted by patients compared to HA fillers 1
  • Additional benefits: Stimulates collagen regeneration over time 1

Treatment Protocol

A typical bio filler treatment involves:

  1. Blood collection from the patient
  2. Centrifugation at 2000g for 8 minutes
  3. Collection of platelet-poor plasma
  4. Heating PPP at 75°C for 10 minutes to create albumin gel
  5. Cooling to room temperature
  6. Mixing with liquid PRF using a luer lock connector
  7. Injection using a 25-gauge needle or cannula 1

Clinical Efficacy

Research demonstrates bio filler's effectiveness:

  • Studies show significant improvement in facial wrinkles and tear trough deformities
  • Wrinkle Severity Rating Scale decreased from 3.18 at baseline to 1.65 after 3 months
  • Tear Trough Rating Scale decreased from 15.67 at baseline to 7.0 after 3 months 1

Practical Considerations

When considering bio filler treatment:

  • Specialized equipment is required (Bio-HEAT apparatus)
  • Practitioner expertise is essential for proper preparation and injection
  • Results are not immediate but develop over time as collagen is stimulated
  • Multiple sessions may be needed for optimal results

Potential Limitations

Important considerations before choosing bio filler:

  • Results are temporary (4-6 months) compared to semi-permanent fillers 1, 5
  • Not ideal for significant volume loss (better for fine lines and wrinkles)
  • Requires specialized equipment that not all practices may have
  • Limited research on long-term outcomes compared to traditional fillers

Bio filler represents a cost-effective alternative to traditional dermal fillers, particularly for patients seeking natural results with lower risk of complications and at a more accessible price point.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Guideline

Cryotherapy for Benign Lesions

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Research

Complications of fillers: overview.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2005

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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