From the Research
Relationship Between Nodular Lymphocyte-Predominant Hodgkin Lymphoma (NLPHL) and Sweet Syndrome
There are no research papers to assist in answering this question, as none of the provided studies mention Sweet Syndrome in relation to NLPHL.
Characteristics of NLPHL
- NLPHL is a rare subtype of Hodgkin lymphoma, accounting for approximately 5% of all Hodgkin lymphoma cases 1
- It has distinct clinicopathologic features, including the presence of malignant LP cells, which are CD20(+)CD15(-)CD30(-) variants of Reed-Sternberg cells 2
- NLPHL often presents with limited stage disease, and the standard treatment is involved field radiotherapy at 30-36 Gy 2
- The prognosis of NLPHL is very favorable, despite frequent and often late or multiple relapses 3
Treatment Approaches for NLPHL
- Treatment can range from active surveillance in asymptomatic patients to aggressive chemotherapeutic agents in advanced disease 4
- Guidelines on chemotherapy regimens are limited due to a lack of randomized-controlled studies, and treatment approaches are often similar to those used in classical Hodgkin lymphoma 4
- High-grade transformation of NLPHL can occur, and the incidence of transformation is around 17.0% 5