Differential Diagnosis for Petechia on Lower Extremities
Single Most Likely Diagnosis
- Immobilization or Stasis: Prolonged periods of standing, sitting, or immobilization can lead to increased venous pressure in the lower extremities, resulting in petechiae due to minor vessel rupture.
Other Likely Diagnoses
- Vitamin Deficiencies (Vitamin C or K): Deficiencies in these vitamins can affect blood vessel integrity and coagulation, leading to petechiae.
- Medication Side Effects (e.g., anticoagulants, steroids): Certain medications can increase the risk of bleeding or affect blood vessel walls, causing petechiae.
- Infections (e.g., meningococcemia, sepsis): Severe infections can lead to petechiae due to disseminated intravascular coagulation (DIC) or direct vascular damage.
- Thrombocytopenia: Low platelet count can increase the risk of bleeding, including petechiae.
Do Not Miss Diagnoses
- Meningococcemia: A severe, life-threatening infection that can cause petechiae, especially in the context of fever, headache, and neck stiffness.
- Disseminated Intravascular Coagulation (DIC): A condition characterized by both widespread clotting and bleeding, which can be triggered by severe infections, trauma, or malignancies.
- Leukemia or Lymphoma: Certain types of cancer can cause petechiae due to bone marrow suppression, leading to thrombocytopenia or platelet dysfunction.
- Vasculitis (e.g., Henoch-Schönlein purpura): Inflammation of blood vessels can cause petechiae, along with other symptoms like joint pain and abdominal pain.
Rare Diagnoses
- Ehlers-Danlos Syndrome: A genetic disorder affecting connective tissue, which can lead to fragile blood vessels and petechiae.
- Scurvy: A disease caused by severe vitamin C deficiency, characterized by petechiae, among other symptoms like malaise and joint pain.
- Amyloidosis: A condition where abnormal proteins (amyloid) accumulate in various tissues, including blood vessels, potentially causing petechiae.
- Thrombotic Thrombocytopenic Purpura (TTP): A rare blood disorder characterized by thrombocytopenia, microangiopathic hemolytic anemia, and petechiae, among other symptoms.