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Last updated: July 28, 2025View editorial policy

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Differential Diagnosis for Testicle Pain

  • Single most likely diagnosis
    • Epididymitis: This is the most common cause of testicle pain, especially in young men. It is usually caused by a bacterial infection and is characterized by pain, swelling, and inflammation of the epididymis.
  • Other Likely diagnoses
    • Orchitis: Inflammation of one or both testicles, usually caused by a viral or bacterial infection. It can cause severe pain, swelling, and redness of the testicle.
    • Testicular torsion (partial): A condition where the spermatic cord becomes twisted, cutting off the blood supply to the testicle. It can cause severe pain, swelling, and nausea.
    • Varicocele: An enlargement of the veins within the scrotum, similar to varicose veins. It can cause a dull ache or feeling of heaviness in the testicle.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Testicular torsion (complete): A medical emergency that requires immediate attention. If left untreated, it can lead to the death of the testicle and potentially life-threatening complications.
    • Testicular cancer: Although rare, testicular cancer can cause pain, swelling, or a lump in the testicle. Early detection is crucial for effective treatment.
    • Appendicitis (with referred pain): In some cases, appendicitis can cause referred pain to the testicle. If left untreated, appendicitis can lead to life-threatening complications.
  • Rare diagnoses
    • Henoch-Schönlein purpura: A rare condition that causes inflammation of the blood vessels, which can lead to testicle pain, swelling, and bruising.
    • Polyarteritis nodosa: A rare autoimmune disorder that can cause inflammation of the blood vessels, leading to testicle pain, swelling, and other systemic symptoms.
    • Spermatic cord cyst: A rare condition where a cyst forms on the spermatic cord, causing pain, swelling, and discomfort in the testicle.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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