What is the recommended treatment for lactational mastitis?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: July 28, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Treatment of Lactational Mastitis

The first-line treatment for lactational mastitis is continued breastfeeding with proper milk removal, supportive measures including pain management with NSAIDs, and antibiotics effective against Staphylococcus aureus if symptoms persist beyond 24-48 hours of conservative management. 1, 2

Diagnosis and Initial Assessment

Lactational mastitis affects approximately 10% of breastfeeding women, typically occurring within the first three months postpartum 2. The diagnosis is primarily clinical, based on:

  • Focal breast tenderness
  • Overlying skin erythema or hyperpigmentation
  • Systemic symptoms (fever, malaise)
  • Recent history of breastfeeding

Treatment Algorithm

Step 1: Conservative Management (First 24-48 hours)

  • Continue breastfeeding from the affected breast to prevent engorgement and worsening of symptoms 1
  • Apply cold compresses to the affected area to reduce inflammation
  • Take pain medications compatible with breastfeeding:
    • Ibuprofen (first choice) 1
    • Paracetamol/acetaminophen (alternative) 1
  • Ensure proper infant latch and breastfeeding technique
  • Avoid excessive pumping, aggressive breast massage, or overfeeding, as these may worsen the condition 2

Step 2: Antibiotic Therapy (If no improvement after 24-48 hours)

  • Initiate antibiotics effective against Staphylococcus aureus:
    • Dicloxacillin 500 mg orally four times daily for 10-14 days 3
    • Cephalexin 500 mg orally four times daily for 10-14 days (alternative) 3
  • Consider obtaining milk cultures to guide antibiotic therapy in cases of:
    • Severe symptoms
    • No response to initial antibiotics
    • Recurrent mastitis
    • Hospital-acquired infections

Step 3: Management of Complications

  • If symptoms worsen despite antibiotics, evaluate for breast abscess using ultrasonography 2
  • For confirmed abscess: surgical drainage or needle aspiration is required 3
  • Continue breastfeeding even with a treated abscess 3

Special Considerations

Continuing Breastfeeding During Treatment

Continuing breastfeeding during mastitis treatment is strongly recommended because:

  • It helps prevent engorgement and blocked ducts 1
  • Stopping breastfeeding may lead to early cessation altogether 1
  • It does not pose a risk to the infant 3

Antibiotic Selection

  • With increasing prevalence of methicillin-resistant S. aureus (MRSA), consider alternative antibiotics if initial therapy fails 3
  • All recommended antibiotics are compatible with breastfeeding 4

Prevention Strategies

  • Optimize breastfeeding technique with proper infant latch 2
  • Encourage physiologic breastfeeding rather than pumping when possible 2
  • Avoid practices that overstimulate milk production 2

Common Pitfalls to Avoid

  1. Stopping breastfeeding during mastitis treatment - This can worsen engorgement and prolong recovery
  2. Excessive pumping or aggressive breast massage - These practices can cause tissue trauma and worsen inflammation 2
  3. Delaying antibiotic therapy - If symptoms don't improve with conservative measures within 24-48 hours, antibiotics should be started promptly
  4. Missing a breast abscess - Consider ultrasonography in immunocompromised patients or those with worsening/recurrent symptoms 2

By following this evidence-based approach to lactational mastitis management, most cases can be effectively treated in the outpatient setting while supporting continued breastfeeding.

References

Guideline

Management of Mastitis in Breastfeeding Mothers

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Research

Mastitis: Rapid Evidence Review.

American family physician, 2024

Research

Management of mastitis in breastfeeding women.

American family physician, 2008

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.