From the Guidelines
To support liver detoxification in patients with Gilbert's syndrome, a healthy and varied diet that includes plenty of fruits, vegetables, and protein is recommended, as there is no specific food that damages the liver or is contraindicated in these patients. The most recent and highest quality study on nutrition in chronic liver disease, including Gilbert's syndrome, suggests that a balanced diet with adequate calories and protein is more important than avoiding specific foods 1. Key dietary recommendations include:
- Eating a variety of foods, including fruits, vegetables, and whole grains
- Consuming adequate amounts of calories and protein
- Splitting food intake into 3 main meals and 3 snacks, with a late-evening snack to cover the interval between dinner and breakfast
- Limiting salt intake, but not at the expense of overall calorie and protein intake
- Considering individual dietary needs, such as those with hepatic encephalopathy, diabetes, or overweight/obesity, and consulting with a doctor or dietician before making any changes. It is also important to note that fasting, such as during Ramadan, may be tolerated by some patients with Gilbert's syndrome, but regular follow-up of bilirubin levels is recommended 1. However, the primary focus should be on maintaining a healthy and balanced diet, rather than avoiding specific foods or fasting, to support liver detoxification and overall health in patients with Gilbert's syndrome.
From the Research
Dietary Support for Liver Detoxification in Gilbert's Syndrome
Dietary support can play a crucial role in aiding liver detoxification in patients with Gilbert's syndrome. The following points highlight the key aspects of dietary support:
- A nutritional intervention consisting of not applying excessive calorie restrictions and consuming fats and biologically active compounds in vegetables and fruits (Cruciferae, Apiaceous, Rutaceae) may prevent the occurrence of jaundice episodes 2.
- Consumption of various diet variants, and vegetables and fruits can have an impact on hyperbilirubinemia and metabolic health in patients with Gilbert's syndrome 2.
- A diet that emphasizes controlling the metabolic state without exposing the liver to unnecessary metabolic stress can be beneficial for patients with liver disease, including those with Gilbert's syndrome 3.
- There is no direct evidence to suggest specific dietary restrictions or supplements that can aid liver detoxification in Gilbert's syndrome, but a balanced diet with adequate nutrition can help support liver function 3, 2.
Key Foods and Compounds
Some key foods and compounds that may be beneficial for patients with Gilbert's syndrome include:
- Vegetables and fruits, particularly those from the Cruciferae, Apiaceous, and Rutaceae families 2.
- Fats and biologically active compounds found in these foods, which may influence the expression of the UGT liver enzyme gene and help regulate bilirubin concentration in the blood 2.
- A balanced diet that includes a variety of whole foods and avoids excessive calorie restriction 2.