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Last updated: July 29, 2025View editorial policy

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Differential Diagnosis for Skin Rash

  • Single Most Likely Diagnosis
    • Atopic Dermatitis (Eczema): This is a common condition characterized by itchy, inflamed skin. It's often seen in individuals with a history of allergies or asthma, and its chronic nature makes it a frequent diagnosis for skin rashes.
  • Other Likely Diagnoses
    • Contact Dermatitis: An allergic or irritant reaction to substances like soaps, detergents, or metals, leading to a skin rash. This is common and can occur in anyone, depending on exposure.
    • Psoriasis: An autoimmune condition causing thick, scaly, red plaques. It's relatively common and can be triggered by various factors, including stress and certain medications.
    • Seborrheic Dermatitis: A condition causing scaly patches, red skin, and stubborn dandruff, often affecting oily areas of the body. It's common and can be associated with stress and neurological conditions.
  • Do Not Miss Diagnoses
    • Meningococcemia: A severe infection that can cause a rash, often accompanied by fever, headache, and stiff neck. It's life-threatening and requires immediate medical attention.
    • Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis: Severe skin and mucous membrane disorders, usually a reaction to medication or infection. These conditions are medical emergencies due to their high mortality rate.
    • Lyme Disease: Caused by a tick bite, leading to a distinctive "bull's-eye" rash, fever, headache, and fatigue. If untreated, it can lead to serious complications.
  • Rare Diagnoses
    • Pemphigus: A group of autoimmune diseases causing blistering of the skin and mucous membranes. It's rare but can be life-threatening if not treated.
    • Dermatomyositis: An inflammatory disease characterized by skin rash and muscle weakness. It's rare and can be associated with underlying malignancies.
    • Kawasaki Disease: A condition mainly affecting children, causing fever, rash, swelling of hands and feet, and other symptoms. It's rare but can lead to serious cardiac complications if not treated promptly.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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