From the Research
Ayahuasca use is associated with significant risks, including psychiatric and non-psychiatric events, and its benefits for managing depression and other mental health disorders are mixed and generally short-lived, therefore, it should be used with caution and under the guidance of experienced professionals. The effects of ayahuasca, a psychotropic drink made from the Amazonian vine Banisteriopsis caapi, can last 4-6 hours and include intense visual and auditory hallucinations, vomiting, and diarrhea 1.
Key Findings
- Ayahuasca contains the psychedelic tryptamine N,N-Dimethyltryptamine (DMT) and Monoamine Oxidase Inhibitors (MAOi), which can interact with various medications and pose risks for people with certain mental health conditions or heart problems 2.
- Recent studies have shown encouraging results regarding the antidepressant effects of ayahuasca, with significant and rapid improvements in depressive symptoms starting as early as 1 day after the ayahuasca intervention 2.
- However, the evidence on the benefits of ayahuasca for managing depression and other mental health disorders is mixed, with some studies suggesting improvements in mindfulness measures and creativity, while others report potential harm and interactions 1, 3.
- Ayahuasca users have reported greater well-being and less problematic drinking compared to classic psychedelic users and non-psychedelic drug-using respondents, but the acute subjective effects of ayahuasca can be intense and may necessitate the presence of an experienced leader to maximize therapeutic benefits 4, 5.
Recommendations
- Ayahuasca should only be used in appropriate ceremonial contexts with experienced guides, and individuals with certain mental health conditions or heart problems should exercise caution when considering its use.
- Further research is needed to fully understand the effects of ayahuasca and its potential therapeutic benefits, particularly in the context of Western therapeutic settings.
- Individuals considering ayahuasca use should be aware of the potential risks and benefits and should consult with a healthcare professional before using the substance.