What is the most accurate laboratory test for measuring vitamin D (25-hydroxyvitamin D) levels?

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From the Guidelines

The most accurate laboratory test for measuring vitamin D (25-hydroxyvitamin D) levels is High-Performance Liquid Chromatography (HPLC) or Liquid Chromatography-Tandem Mass Spectrometry (LC/MS-MS).

Key Considerations

  • These assays should measure both 25(OH)D2 and 25(OH)D3 and indicate the sum of the two compounds as the main result 1.
  • Laboratories should participate in an external quality control scheme, such as the UK-based DEQAS, which provides materials with documented commutability with human sera 1.
  • An internal quality control program should be carried out using different levels of samples and valuable criteria for rejecting or accepting analytical runs 1.
  • Serum is the sample of choice, and results should be expressed in ng/mL 1.
  • It is recommended to avoid using population-based reference values and instead use a recommended range for 25(OH)D to avoid confusion 1.

From the Research

Laboratory Tests for Measuring Vitamin D Levels

The most accurate laboratory test for measuring vitamin D (25-hydroxyvitamin D) levels is a topic of interest in clinical medicine.

  • The most abundant vitamin D metabolite, 25-hydroxyvitamin D, is considered the best marker for estimating vitamin D status and is therefore the most commonly measured in clinical practice 2, 3, 4.
  • Automated immunoassays are the most frequently used methods for measuring 25-hydroxyvitamin D, but they do not meet the requirements of today's standards for certain patient groups 2, 3.
  • Liquid chromatography-tandem mass spectrometry is considered the desired method of choice for measuring 25-hydroxyvitamin D in certain individuals due to its high accuracy and precision 2, 5.
  • Other methods, such as high-performance liquid chromatography (HPLC), are also available but have limitations, including lack of sensitivity for determining trace amounts of 25-hydroxyvitamin D2 and D3 5.

Comparison of Assays

  • Different assays for measuring 25-hydroxyvitamin D have been compared, and significant differences remain among various methods and laboratories 3.
  • Standardization of analytical methods is essential for developing and implementing evidence-based clinical guidelines and achieving comparable results via different methods 5.
  • The measurement of free 25-hydroxyvitamin D is also of interest, and new immunoassays have been developed to measure it directly, but calculated values using levels of total 25-hydroxyvitamin D, albumin, and vitamin D binding protein are still commonly used 6.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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