Differential Diagnosis for Eyebrow Lesion

• Single most likely diagnosis
  • Seborrheic keratosis: This is a common, benign skin growth that can appear on the face, including the eyebrow area. It is often pigmented and can be mistaken for a melanoma, but it tends to have a more warty or stuck-on appearance.
• Other Likely diagnoses
  • Basal cell carcinoma: This is the most common form of skin cancer and can appear in the eyebrow area. It often presents as a small, shiny bump, but can also appear as a sore or a red patch.
  • Squamous cell carcinoma: Another form of skin cancer, squamous cell carcinoma can appear as a firm, red nodule or a flat sore in the eyebrow area.
  • Melanocytic nevus (mole): A benign growth of pigment-producing cells called melanocytes, moles can appear anywhere on the body, including the eyebrows.
  • Cyst (sebaceous or epidermoid): Cysts can form in the eyebrow area due to blockage of sebaceous or sweat glands, appearing as a lump or bump under the skin.
• Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
  • Melanoma: Although less common than other skin cancers, melanoma is the most dangerous form of skin cancer. It can appear as a new or changing mole in the eyebrow area, and early detection is crucial for treatment.
  • Merkel cell carcinoma: A rare and aggressive skin cancer that can appear as a firm, painless nodule in the eyebrow area.
• Rare diagnoses
  • Dermatofibroma: A rare, benign skin growth that can appear as a firm, round bump in the eyebrow area.
  • Trichoepithelioma: A rare, benign tumor of hair follicle origin that can appear as a small, firm nodule in the eyebrow area.
  • Metastatic cancer: In rare cases, cancer from another part of the body can metastasize to the skin, including the eyebrow area, although this would be extremely uncommon as a first presentation.