From the Research
I would not recommend taking L-arginine and L-citrulline supplements if you are also taking tarantula venom or extracts, as the potential interaction between these substances could lead to adverse cardiovascular effects, including excessive blood pressure lowering. The amino acid supplements L-arginine and L-citrulline increase nitric oxide production in the body, which can lower blood pressure and increase blood flow 1, 2, 3. Some tarantula venoms contain peptides that affect cardiovascular function, and combining these with vasodilating supplements could potentially cause excessive blood pressure lowering. Although research on this specific interaction is limited, it is essential to exercise caution when using these supplements in conjunction with tarantula-derived compounds. If you're using tarantula-derived compounds for medicinal purposes, consult with your healthcare provider before adding any supplements 4, 5. The same caution applies if you're handling tarantulas and concerned about potential envenomation. If you're taking these supplements for exercise performance or other health reasons, it would be safer to temporarily discontinue them when working with tarantulas or using tarantula-derived products.
Key considerations:
- L-arginine and L-citrulline supplements can increase nitric oxide production, leading to vasodilation and potential hypotension
- Tarantula venom contains peptides that can affect cardiovascular function, potentially interacting with L-arginine and L-citrulline supplements
- Limited research is available on the specific interaction between L-arginine, L-citrulline, and tarantula venom, making caution essential
- Consultation with a healthcare provider is recommended before using these supplements in conjunction with tarantula-derived compounds
In terms of the evidence, the most recent and highest-quality study on the topic of L-arginine and L-citrulline supplementation is the 2025 systematic review and meta-analysis published in BJOG: an international journal of obstetrics and gynaecology 4. This study found that L-arginine may be effective in reducing pre-eclampsia and related outcomes, but the evidence is still limited, and more research is needed to determine the optimal dose and timing of supplementation. However, this study does not directly address the interaction between L-arginine, L-citrulline, and tarantula venom, highlighting the need for caution and consultation with a healthcare provider.