Docusate Sodium (Peri-Colace) Dosing for Constipation
Yes, you can take Peri-Colace (docusate sodium) twice daily as this aligns with the FDA-approved dosing guidelines for adults.
Recommended Dosing
According to the FDA label for docusate sodium:
- Adults and children 12 years and older: 1 to 3 softgels daily, which may be taken as a single daily dose or in divided doses 1
- This means taking Peri-Colace twice daily is within the recommended dosing range
Efficacy Considerations
It's important to note that while docusate sodium is commonly prescribed, evidence suggests it has limited effectiveness for constipation:
- Psyllium has been shown to be superior to docusate sodium for treating chronic constipation by better increasing stool water content and overall laxative efficacy 2
- A systematic review found insufficient evidence to support docusate's efficacy in opioid-induced constipation compared to other agents 3
- A randomized controlled trial in hospice patients found no significant benefit of docusate plus sennosides compared to placebo plus sennosides 4
Better Alternatives
For more effective constipation management:
- Polyethylene glycol (PEG) 17g daily mixed in 8oz water is recommended as first-line treatment for constipation 5
- Alternative options include:
- Magnesium oxide 400-500 mg daily
- Bisacodyl 5-10 mg daily
- Senna 8.6-17.2 mg daily 5
Administration Tips
When taking docusate sodium:
- Take with a full glass of water 1
- Ensure adequate hydration throughout the day
- Allow 12-72 hours for effect
Monitoring
- If no improvement in constipation symptoms occurs within 72 hours, consider switching to a more effective agent like PEG
- Monitor for adverse effects, which are generally mild but can include abdominal cramping
When to Seek Medical Advice
Consult a healthcare provider if:
- Constipation persists despite taking docusate sodium as directed
- You experience severe abdominal pain
- You notice blood in your stool
- You have not had a bowel movement for more than 7 days
While docusate sodium twice daily is safe according to FDA guidelines, its effectiveness is questionable, and other laxative options may provide better relief for constipation.