Does microneedling improve topical absorption of Nicotinamide Adenine Dinucleotide (NAD)?

Microneedling for Enhanced Topical NAD Absorption

Microneedling can significantly enhance topical absorption of NAD by creating temporary microchannels in the skin that allow for improved penetration of the substance through the stratum corneum barrier. 1, 2

Mechanism of Action

Microneedling works through several mechanisms that facilitate improved topical absorption:

• Creates controlled micro-injuries using small needles that penetrate the skin at depths of 0.25-2.5 mm 1
• Produces microchannels that temporarily bypass the stratum corneum barrier 2
• Stimulates the wound-healing cascade while simultaneously allowing topical substances to penetrate deeper into the skin 1
• Microchannels created with non-thermal needling remain open for 4-6 hours due to fibrin plugs, providing a window for enhanced absorption 3

Optimal Application Technique

For maximum NAD absorption through microneedling:

1. Preparation:

   • Apply topical anesthesia for at least 30 minutes prior to the procedure 1
   • Ensure the skin is thoroughly cleansed before treatment

2. Device Selection and Settings:

   • Use an electrically powered microneedling device that delivers a vibrating, stamp-like motion 1
   • Adjust needle depth between 0.25-2.5 mm based on treatment area:
     • Forehead and periorbital areas: 0.25-0.5 mm
     • Cheeks: 0.5-1.5 mm
     • Perioral region: 0.5-1.0 mm

3. Application Technique:

   • Ensure skin is well lubricated with the NAD solution during the procedure to avoid dry tugging sensation 4
   • Apply NAD topically immediately before, during, and/or after microneedling while channels remain open 3
   • Follow directional guidelines specific to facial regions for optimal penetration 1

Clinical Considerations

• Timing is critical: Apply NAD within the 4-6 hour window when microchannels remain open 3
• Enhanced delivery: Microneedling can increase absorption of topical substances by 5-10 times compared to topical application alone 5
• Treatment frequency: Schedule sessions 2-4 weeks apart for optimal results 1
• Safety profile: Microneedling has minimal downtime (24-48 hours) and is suitable for all skin types 1

Important Precautions

• Do not microneedle over tattoos, permanent makeup, or active skin infections 1
• Wait 24-48 hours after microneedling before applying additional active ingredients to avoid excessive irritation 1
• Use strict sun protection with broad-spectrum SPF 70 or higher following the procedure 1
• Be aware that combining NAD with microneedling may technically classify it as a drug delivery system according to FDA considerations 3

Potential Advantages

• Preserves the epidermis while creating controlled pathways for absorption 2
• Reduces inflammation, downtime, and risk of dyspigmentation compared to ablative procedures 2
• Can be combined with other penetration enhancement techniques like iontophoresis or sonophoresis for even greater absorption 5

Microneedling represents an effective approach for enhancing NAD absorption through the skin with minimal risk and downtime, making it a valuable option for those seeking to maximize the benefits of topical NAD applications.