From the Guidelines
Lisdexamfetamine is the generic name for Vyvanse. The medication is a prodrug stimulant primarily used to treat attention deficit hyperactivity disorder (ADHD) and moderate to severe binge eating disorder, as noted in a study published in the American Journal of Obstetrics and Gynecology 1. It works by being converted in the body to dextroamphetamine, which increases levels of neurotransmitters like dopamine and norepinephrine in the brain.
Key Characteristics of Lisdexamfetamine
- It is a prodrug stimulant medication
- Primarily used to treat ADHD and moderate to severe binge eating disorder
- Works by being converted to dextroamphetamine in the body
- Increases levels of dopamine and norepinephrine in the brain
Clinical Use and Considerations
Unlike some other ADHD medications, Vyvanse's unique prodrug formulation means it must be metabolized by the body to become active, which contributes to its longer duration of action (typically 10-14 hours) and potentially lower abuse potential compared to immediate-release stimulants, as discussed in a study published in Pharmacology and Therapeutics 1. When generic versions eventually become available, they will contain the same active ingredient (lisdexamfetamine) as the brand-name medication.
Important Considerations for Prescribers
- Monitor for potential side effects such as decreased appetite, sleep disturbances, and increased blood pressure and pulse
- Consider the patient's individual needs and symptom profile when selecting a formulation
- Be aware of the potential for rebound effects and the importance of medication adherence
Overall, lisdexamfetamine is an effective treatment option for ADHD and binge eating disorder, with a unique mechanism of action and potential benefits in terms of duration of action and abuse potential. As with any medication, prescribers should carefully consider the potential benefits and risks, as well as individual patient needs, when making treatment decisions.
From the FDA Drug Label
Lisdexamfetamine dimesylate capsules, a CNS stimulant, are for once-a-day oral administration. The generic name for Vyvanse is lisdexamfetamine 2.
From the Research
Generic Name for Vyvanse
Mechanism of Action
- Lisdexamfetamine is a prodrug that is hydrolyzed to its active form, d-amphetamine, in the blood following oral administration 4, 5, 6.
- D-amphetamine competitively inhibits the dopamine transporter (DAT) and the noradrenaline transporter (NAT) to increase dopamine (DA) and noradrenaline (NA) concentrations in the synaptic cleft 4.