What is the recommended dosage of Zifi CV (Cefixime and Clavulanate) for adults and children over 12 years?

Recommended Dosage of Zifi CV (Cefixime and Clavulanate)

For adults and children over 12 years, the recommended dosage of Zifi CV is 400 mg of cefixime once daily, which may be administered as a single dose or divided into two doses of 200 mg twice daily. 1

Dosage Guidelines Based on FDA Label

The FDA-approved dosage for cefixime in adults is 400 mg daily, which can be administered as a single dose or divided into two doses. This applies to Zifi CV as well, which contains cefixime as its primary active ingredient along with clavulanate. 1

For children over 12 years who weigh more than 45 kg, the adult dosage of 400 mg daily is recommended. 1

Dosage Considerations

• Single vs. Divided Doses: While a single daily dose of 400 mg is convenient, dividing the dose into 200 mg twice daily may reduce gastrointestinal side effects. 2

• Administration with Food: The medication may be administered without regard to food. 1

• Duration of Treatment:

  • For most infections: 7-14 days
  • For Streptococcus pyogenes infections: minimum 10 days 1
  • For uncomplicated urinary tract infections: 7-10 days

Special Populations

Renal Impairment

For patients with impaired renal function, dosage adjustments are necessary:

• Creatinine clearance 21-59 mL/min: 300 mg once daily
• Creatinine clearance ≤20 mL/min or on hemodialysis: 200 mg once daily 1

Common Indications for Zifi CV

Zifi CV is indicated for:

1. Uncomplicated urinary tract infections
2. Otitis media
3. Pharyngitis and tonsillitis
4. Acute exacerbations of chronic bronchitis
5. Uncomplicated gonorrhea 1

Common Side Effects

The most common adverse effects are:

• Diarrhea (more common with single daily dosing)
• Abdominal pain
• Nausea
• Headache 3

Important Considerations

• Pediatric Use: For children between 6 months and 12 years, the recommended dose is 8 mg/kg/day, which may be given as a single daily dose or divided into two doses. 1

• Efficacy: Clinical studies have shown cefixime to be effective in respiratory and urinary tract infections with cure rates of 94-100% in properly selected patients. 4

• Clavulanate Component: The clavulanate in Zifi CV helps overcome beta-lactamase resistance, making it effective against beta-lactamase producing organisms.

Always complete the full course of antibiotics as prescribed, even if symptoms improve before the course is finished, to prevent the development of antibiotic resistance.