What is the other name for Truvada (Emtricitabine/Tenofovir Disoproxil Fumarate)?

Other Names for Truvada (Emtricitabine/Tenofovir Disoproxil Fumarate)

Truvada is a combination medication containing emtricitabine (FTC) 200 mg and tenofovir disoproxil fumarate (TDF) 300 mg in a single tablet. This fixed-dose combination is widely used for both HIV treatment and prevention.

Brand and Generic Names

• Brand name: Truvada
• Generic name: Emtricitabine/Tenofovir Disoproxil Fumarate (FTC/TDF)

Formulations and Availability

Truvada is available as:

• A single tablet containing 200 mg emtricitabine and 300 mg tenofovir disoproxil fumarate
• Generic versions are available in many countries since Truvada's patent expiration

Clinical Uses

Truvada is primarily used for:

1. HIV Treatment:

   • As part of combination antiretroviral therapy (ART) regimens
   • Often combined with a third agent from another antiretroviral class 1
   • Particularly valuable in patients co-infected with HIV and hepatitis B virus (HBV) 1

2. HIV Pre-Exposure Prophylaxis (PrEP):

   • For high-risk individuals to prevent HIV acquisition
   • Standard daily dosing: one tablet daily 1
   • For MSM only: optional 2-1-1 (on-demand) dosing available 2

Pharmacological Properties

• Both components (emtricitabine and tenofovir) have activity against HIV-1, HIV-2, and hepatitis B virus 3
• Long half-lives in plasma and peripheral blood mononuclear cells allow for once-daily dosing 3
• Both components are eliminated renally and require dose adjustment in patients with renal impairment 1

Considerations in Clinical Practice

• Truvada is not recommended for patients with creatinine clearance <60 mL/min 1
• Regular monitoring is essential during treatment, including HIV testing, renal function, and STI screening 1
• Emtricitabine can be interchanged with lamivudine in most clinical scenarios but has a higher genetic barrier to resistance 1
• Discontinuation in patients with HBV can cause severe acute exacerbations of hepatitis B 1

International Recognition

Truvada is recognized globally as a cornerstone of HIV treatment and prevention strategies, with approvals in the United States, European Union, Australia, Iceland, Brazil, Canada, Switzerland, and Japan 4.

The combination of emtricitabine and tenofovir disoproxil fumarate in Truvada represents an important advancement in HIV management, offering simplified dosing and demonstrated efficacy in both treatment and prevention contexts.