Does serrapeptase contain histamine?

Does Serrapeptase Contain Histamine?

Serrapeptase does not contain histamine. Serrapeptase is a proteolytic enzyme derived from bacteria, not a source of histamine itself 1, 2.

What is Serrapeptase?

Serrapeptase (also known as serratiopeptidase) is:

• A proteolytic enzyme originally isolated from the intestine of silkworms and produced by the bacteria Serratia marcescens 3
• Used clinically for its purported anti-inflammatory, anti-edemic, and analgesic properties 1, 2
• Prescribed in various specialties including surgery, orthopedics, otorhinolaryngology, gynecology, and dentistry 1

Relationship to Histamine

While serrapeptase itself does not contain histamine, it's important to understand several key points:

1. Not a histamine source: Unlike certain foods (particularly fermented foods) that naturally contain high levels of histamine, serrapeptase is an enzyme, not a source of histamine 4.

2. Inflammatory processes: Serrapeptase is used to reduce inflammation by:

   • Targeting cyclooxygenase enzymes (COX-I and COX-II) that produce inflammatory mediators 2
   • Demonstrating fibrinolytic and caseinolytic properties 1

3. Potential considerations for sensitive individuals:

   • Individuals with histamine intolerance (reduced diamine oxidase activity) should be cautious with any supplement that might influence inflammatory pathways 4
   • Those with mast cell disorders should discuss any enzyme supplement with their healthcare provider 5

Clinical Implications

For patients concerned about histamine-related reactions:

• Monitoring: If taking serrapeptase and experiencing symptoms that mimic allergic reactions (flushing, headache, rhinoconjunctival symptoms, urticaria, etc.), consider monitoring for histamine-related reactions 5

• Diagnostic considerations: In case of suspected reactions, diagnostic tests might include:

  • Serum tryptase (optimal collection 15 min to 3 hours after symptoms) 5
  • Urinary histamine metabolites (can be detected up to 24 hours) 5

• Caution in certain conditions: Use caution with serrapeptase in:

  • Abscess conditions due to its fibrinolytic activity 6
  • Patients with known mast cell disorders 5

Evidence Quality

The overall scientific evidence for serrapeptase's clinical efficacy is limited:

• Most studies have poor methodology with small sample sizes 1
• Long-term safety data is lacking 1
• Evidence-based recommendations on efficacy and safety are needed 1

Bottom Line

Serrapeptase itself is not a source of histamine. However, as with any supplement, individuals with histamine intolerance or mast cell disorders should exercise caution and consult with their healthcare provider before use.