American College of Cardiology/American Heart Association Recommendations for Evaluation of Chest Pain
The evaluation of chest pain requires a focused history, physical examination, and appropriate diagnostic testing to identify potentially life-threatening causes, with an ECG obtained within 10 minutes of presentation for all patients with acute chest pain. 1
Initial Assessment and History Taking
Key Components of History
- Characteristics of pain: Obtain detailed information about:
- Nature (pressure, heaviness, tightness vs. sharp, stabbing)
- Onset and duration
- Location and radiation
- Severity
- Precipitating factors (exertion, emotional stress)
- Relieving factors
- Associated symptoms 1
Pain Descriptors and Ischemia Risk
- Higher probability of ischemia: Central, pressure, heaviness, tightness, exertional/stress-related, retrosternal, squeezing, dull
- Lower probability of ischemia: Stabbing, fleeting, sharp, pleuritic, positional, reproducible by palpation 1
Special Considerations for High-Risk Populations
Women
- Women with chest pain are at risk for underdiagnosis
- Always consider potential cardiac causes in women
- Obtain history emphasizing accompanying symptoms more common in women with ACS 1
Older Patients (≥75 years)
- Consider ACS when accompanying symptoms include:
- Shortness of breath
- Syncope
- Acute delirium
- Unexplained falls 1
Diverse Patient Populations
- Use cultural competency and formal translation services when needed 1
Physical Examination
A focused cardiovascular examination should be performed to aid in diagnosis of ACS or other serious causes of chest pain and identify complications 1.
Key Physical Findings by Condition
- ACS: Diaphoresis, tachypnea, tachycardia, hypotension, crackles, S3, MR murmur
- Pulmonary Embolism: Tachycardia, dyspnea, pain with inspiration
- Aortic Dissection: Pulse differential, connective tissue disorder signs
- Pneumonia: Fever, regional dullness to percussion, egophony
- Pneumothorax: Unilateral decreased/absent breath sounds
- Pericarditis: Friction rub, fever, pain increased in supine position 1
Diagnostic Testing
Electrocardiogram (ECG)
- All patients with acute chest pain: Obtain ECG within 10 minutes of arrival
- Office setting with stable chest pain: Perform ECG unless noncardiac cause is evident
- If ECG unavailable in office: Refer to ED for ECG 1
Cardiac Biomarkers
- ED presentation with suspected ACS: Measure cardiac troponin (cTn) as soon as possible
- Office setting: Avoid delayed transfer to ED for cTn testing 1
Setting-Specific Recommendations
Office/Outpatient Setting
- For stable chest pain: Perform ECG if available
- For suspected ACS or life-threatening causes: Transport urgently to ED via EMS
- Avoid: Delayed transfer to ED for cardiac troponin or other diagnostic testing 1
Emergency Department
- Obtain ECG within 10 minutes
- Measure cardiac troponin promptly
- Consider structured risk assessment protocols 1
Common Pitfalls to Avoid
Terminology pitfall: Do not describe chest pain as "atypical" - instead, categorize as cardiac, possibly cardiac, or noncardiac 1
Diagnostic pitfall: Do not use relief with nitroglycerin as a diagnostic criterion for myocardial ischemia 1
Women and elderly patients: Avoid underdiagnosis by maintaining high suspicion even with less typical presentations 1
Office setting: Do not delay transfer to ED when ACS is suspected 1
Relying solely on chest pain history: The chest pain history alone is not sufficient to rule out ACS without appropriate diagnostic testing 2
By following these evidence-based recommendations from the American College of Cardiology/American Heart Association, clinicians can effectively evaluate chest pain and reduce morbidity and mortality from potentially life-threatening conditions.