What is Meclizine used for?

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Last updated: February 8, 2025View editorial policy

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From the Guidelines

Meclizine is used as an antivertigo agent.

Uses of Meclizine

  • Meclizine is classified under the ATC code R06AD01, which indicates its use as an antihistamine for systemic use, specifically for the treatment of vertigo and other balance disorders 1.
  • The medication is considered sometimes appropriate for use in palliative care, particularly for managing symptoms such as vertigo 1.
  • In the context of advanced dementia care, Meclizine may be used to manage vertigo and other symptoms that affect the patient's quality of life 1.
  • However, the use of Meclizine should be carefully evaluated in patients with limited life expectancy, as its benefits and risks need to be weighed against the patient's goals of care and quality of life 1.

From the FDA Drug Label

MECLIZINE HYDROCHLORIDE tablets, for oral use Initial U. S. Approval: 1957 INDICATIONS AND USAGE Meclizine hydrochloride tablets are indicated for the treatment of vertigo associated with diseases affecting the vestibular system in adults (1).

Meclizine is used for the treatment of vertigo associated with diseases affecting the vestibular system in adults 2.

From the Research

Meclizine Uses

  • Meclizine is used for the treatment of motion sickness and vertigo 3, 4, 5
  • It is an antihistamine that has been widely used for prophylactic treatment and management of motion sickness 4
  • Meclizine is also used to manage nausea and vomiting with few adverse effects 6
  • Additionally, meclizine has shown promise as an anti-eczema treatment, with potential activity against eczema 7

Meclizine Formulations

  • Meclizine is available in various formulations, including oral tablets, suspension, and orodissolvable/dispersible tablets 4, 6
  • A new dual function orodissolvable/dispersible meclizine HCL tablet has been developed to challenge patient inconvenience, with rapid and prolonged efficacy 6
  • Meclizine ointment has also been formulated and studied for its anti-eczema activity, with promising results 7

Meclizine Mechanism of Action

  • Meclizine may not primarily work through sensory-specific mechanisms, but rather on a more central level 3
  • The binding mechanism of meclizine to the histamine H1 receptor has been studied, with conserved binding sites compared to other antihistamines 5

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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