From the Guidelines
Administration Frequency of Risperidone
Risperidone is typically administered once or twice daily.
Details of Administration
- The dose of risperidone can vary, but common doses range from 1.16 mg/day to 4 mg/day 1.
- The administration frequency is usually once or twice daily, with the goal of achieving a stable plasma concentration 1.
- It's essential to note that the dose and administration frequency may need to be adjusted based on the individual patient's response and tolerance to the medication 1.
- In some cases, the dose may be increased at widely spaced intervals (after initial titration, usually 14–21 days) if the response has been inadequate, and then only within the limits of sedation and the emergence of extrapyramidal side-effects 1.
- The administration frequency and dose of risperidone may also depend on the specific condition being treated, such as psychotic disorders or disruptive behaviors 1.
Key Considerations
- Initial target doses for most patients are risperidone 2 mg/day or olanzapine 7.5–10.0 mg/day 1.
- Extrapyramidal side-effects from antipsychotic treatment should be avoided to encourage future adherence to medication 1.
- Families should be included in the assessment process and treatment plan, and this may be particularly relevant in developing countries 1.
From the FDA Drug Label
The total daily dose of RISPERIDONE can be administered once daily, or half the total daily dose can be administered twice daily. RISPERIDONE can be administered once or twice daily. Patients experiencing persistent somnolence may benefit from administering half the daily dose twice daily, or a reduction of the dose. For patients with severe renal impairment (CLcr < 30 mL/min) or hepatic impairment (10 to 15 points on Child Pugh System), the initial starting dose is 0.5 mg twice daily.
The administration frequency of Risperidone can be once daily or twice daily, depending on the patient's response and tolerability.
- For some patients, once daily administration may be suitable.
- For others, twice daily administration may be necessary, such as those experiencing persistent somnolence. 2 2
From the Research
Administration Frequency of Risperidone
The administration frequency of Risperidone can vary depending on the specific formulation and patient population.
- According to a study published in 2021 3, the usual frequency of doses is twice daily.
- However, a study from 1998 4 found that once-daily administration of Risperidone was as effective and safe as twice-daily administration in patients with schizophrenia.
- Another study from 2007 5 compared the equivalent switching dose from oral Risperidone to Risperidone long-acting injection, which is administered every 2 weeks.
- The optimal dosing with Risperidone was updated in 2001 6, recommending a target dose of 4 mg/day for most patients, with less-rapid titration than previously recommended.
- A lower dose and slower titration may be appropriate for certain patient populations, such as the elderly, young patients, and first-episode patients 6.
- Additionally, a study from 1995 7 discussed the pharmacokinetics and clinical overview of Risperidone, but did not specifically address the administration frequency.