Can beta-glucan (β-glucan) exacerbate multiple sclerosis (MS)?

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Last updated: March 6, 2025View editorial policy

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From the Research

Beta glucan is not generally known to aggravate multiple sclerosis (MS), and may actually have potential benefits for some MS patients. Beta glucans are polysaccharides found in certain foods like mushrooms, oats, barley, and yeasts that have immunomodulatory properties. While they can stimulate immune function, which might theoretically be concerning in autoimmune conditions like MS, current evidence doesn't suggest they worsen MS symptoms. In fact, some research indicates beta glucans may help regulate immune responses rather than simply boosting them, potentially reducing inflammation in some contexts. However, MS is a complex disease with varying individual responses, so patients should discuss any supplement with their healthcare provider before starting it. This is especially important because MS medications often work by modulating immune function, and supplements that affect immunity could potentially interact with these treatments. If you have MS and are considering taking beta glucan supplements, consult with your neurologist first to ensure it won't interfere with your current treatment plan or potentially exacerbate your condition based on your specific situation.

Key Considerations

  • MS is a complex disease with varying individual responses, making it essential to consult with a healthcare provider before starting any supplement, including beta glucan.
  • Beta glucans have immunomodulatory properties, which may help regulate immune responses and potentially reduce inflammation in some contexts.
  • Current evidence does not suggest that beta glucans worsen MS symptoms, but individual responses may vary.
  • MS medications often work by modulating immune function, and supplements that affect immunity could potentially interact with these treatments.

Recent Studies

The most recent study on exercise in MS patients, published in 2019 1, suggests that exercise has become a cornerstone of MS rehabilitation and may have even more fundamental benefits in MS, with the potential to change clinical practice again. However, this study does not specifically address the use of beta glucan supplements in MS patients. Another study published in 2018 2 reviews the current treatment options for MS, including oral and parenteral drugs, but does not mention beta glucan supplements.

Recommendations

Patients with MS should consult with their neurologist before starting beta glucan supplements to ensure they won't interfere with their current treatment plan or potentially exacerbate their condition based on their specific situation. It is essential to weigh the potential benefits and risks of beta glucan supplements in the context of individual patient needs and treatment plans.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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