What is the best way to gain muscle?

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Last updated: August 5, 2025View editorial policy

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Best Way to Gain Muscle

The best way to gain muscle is through a combination of resistance exercise training performed 2-3 times per week for each major muscle group, with 3 sets of 8-12 repetitions at 60-70% of 1RM, combined with adequate protein intake of 1.6-2.0 g/kg body weight per day. 1

Resistance Training Program

Training Frequency and Volume

  • Train each major muscle group 2-3 times per week 1
  • Allow at least 48 hours of rest between sessions for the same muscle group 1
  • Perform 2-4 sets per exercise (single sets can be effective for beginners) 1
  • Complete 8-12 repetitions per set for optimal strength and muscle growth 1

Training Intensity

  • Beginners: Start with 40-50% of 1-RM and progress to 60-70% of 1-RM 1
  • Intermediate exercisers: Work at 60-70% of 1-RM 1
  • Advanced exercisers: Train at ≥80% of 1-RM 1
  • Use a Rating of Perceived Exertion (RPE) of 12-14 on the Borg scale (somewhat difficult) 1

Exercise Selection

Include compound exercises that work multiple muscle groups simultaneously:

  • Bench press
  • Lat pulldown
  • Shoulder press
  • Squats
  • Deadlifts
  • Rows 1

Nutritional Strategies

Protein Requirements

  • Consume 1.6-2.0 g/kg body weight per day of protein 1, 2
  • Higher intakes (up to 1.8-2.0 g/kg/day) may be beneficial during caloric restriction to prevent lean mass loss 2
  • Distribute protein intake across 3-4 meals throughout the day 2

Timing of Nutrition

  • Consume protein within the post-exercise window to maximize muscle protein synthesis 3
  • Pre-sleep protein intake (25-30g) can augment muscle mass and strength gains during resistance training 4
  • Ingest carbohydrate/protein before exercise to reduce catabolism and after exercise to promote an anabolic hormonal profile 5

Supplementation

  • Whey protein: Convenient source of high-quality protein
  • Creatine monohydrate: Effective for increasing muscle mass when combined with resistance exercise 1, 5, 6
  • Leucine and branched-chain amino acids: May play a prominent role in stimulating muscle protein synthesis 2, 5

Recovery Strategies

Sleep

  • Get 7-8 hours of sleep per night 1
  • Maintain a consistent sleep schedule 1

Rest Between Workouts

  • Allow adequate recovery between training sessions
  • Incorporate deload weeks periodically to prevent overtraining

Safety Considerations

Proper Form

  • Use proper form through full range of motion
  • Start with lighter weights and progress gradually
  • Avoid the Valsalva maneuver (holding breath during exertion) 1

Warm-up

  • Perform a 5-10 minute warm-up before resistance training
  • Avoid ballistic stretching (bouncing during stretches) 1

Special Populations

Older Adults

  • May benefit from medical clearance before starting a resistance training program
  • Should start with lower intensity and gradually progress 1
  • May require longer recovery periods between training sessions

Medical Conditions

  • Those with cardiovascular disease should follow specific guidelines for resistance training 7
  • Individuals with diabetes can benefit from resistance training to improve insulin sensitivity 7

Monitoring Progress

  • Track strength increases over time
  • Measure body composition changes
  • Adjust training variables (volume, intensity, frequency) as you progress
  • Periodize training to prevent plateaus

By following these evidence-based guidelines for resistance training and nutrition, you can optimize muscle growth while minimizing injury risk. Remember that consistency is key, and results will accumulate over time with dedicated effort to both training and recovery.

References

Guideline

Training and Nutrition Plan

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Research

Exercise, protein metabolism, and muscle growth.

International journal of sport nutrition and exercise metabolism, 2001

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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