From the Research
Mounjaro (tirzepatide) can affect the kidneys, but it's generally considered safe for most patients with normal kidney function, as evidenced by recent studies 1. The medication is primarily cleared by the kidneys, so dose adjustments may be necessary for patients with kidney impairment. In clinical trials, Mounjaro has not shown significant negative effects on kidney function in most patients, however, some patients may experience dehydration due to gastrointestinal side effects like nausea, vomiting, or diarrhea, which could potentially impact kidney function. Patients with pre-existing kidney disease should be monitored more closely while taking Mounjaro, as the medication may actually provide some kidney protection in patients with type 2 diabetes by improving blood sugar control and potentially reducing the progression of diabetic kidney disease, as suggested by research on biomarkers for kidney function 2, 3. Key factors to consider when assessing kidney function in patients taking Mounjaro include:
- Estimated glomerular filtration rate (eGFR) equations, such as the CKD-EPI creatinine equation, which can help identify patients with chronic kidney disease 3
- Serum creatinine levels, which can be used to estimate kidney function, but have limitations, as discussed in recent reviews 4
- Alternative biomarkers, such as cystatin C, which can provide additional information on kidney function, particularly in patients with kidney impairment 1. If you have kidney concerns, it's essential to discuss them with your healthcare provider before starting Mounjaro, as they may recommend specific monitoring or dosage adjustments based on your kidney function.