From the Research
There is no significant interaction between tadalafil and benzonatate, and they can generally be taken together safely. Tadalafil is a phosphodiesterase-5 (PDE5) inhibitor used for erectile dysfunction or benign prostatic hyperplasia, while benzonatate is a non-narcotic antitussive (cough suppressant) that works by numbing stretch receptors in the lungs. They have different metabolic pathways and different effects on the body. Tadalafil is primarily metabolized by the liver enzyme CYP3A4, while benzonatate works locally in the respiratory tract. Neither medication significantly affects the other's effectiveness or safety profile, as supported by the lack of interaction studies suggesting adverse effects between PDE5 inhibitors and non-narcotic antitussives 1, 2.
Some key points to consider when taking these medications together include:
- Tadalafil's cardiovascular benefits and safety profile, as demonstrated in recent studies 2
- The importance of informing healthcare providers about all medications being taken to ensure individual-specific concerns are addressed based on complete medical history and other medications 3, 4
- The different mechanisms of action and metabolic pathways of tadalafil and benzonatate, which suggest a low likelihood of significant interaction 5
However, as with any medications, it's always advisable to inform your healthcare provider about all medications you are taking to ensure there are no individual-specific concerns based on your complete medical history and other medications you may be taking. The most recent and highest quality study on tadalafil's use and safety profile supports its safe use in various patient populations 2.