L-Lysine and Ejaculate Volume: No Evidence of Benefit
There is no scientific evidence supporting the use of L-lysine supplementation to increase semen volume in men. The available medical guidelines and research do not indicate that L-lysine has any beneficial effect on ejaculate volume or other semen parameters in humans.
Current Evidence on Male Reproductive Health
What Affects Ejaculate Volume?
Several factors are known to influence ejaculate volume:
Obesity: Research shows a negative relationship between obesity and ejaculate volume. A longitudinal study of American males reported an increased odds ratio for decreased ejaculate volume associated with obesity 1.
Abstinence period: Longer periods between ejaculations typically result in greater semen volume.
Hydration status: Proper hydration can influence seminal fluid production.
Age: Ejaculate volume tends to decrease with advancing age.
Medical conditions: Conditions affecting the prostate, seminal vesicles, or ejaculatory ducts can reduce semen volume.
Research on Amino Acids and Semen Parameters
While some animal studies have examined amino acid supplementation:
Studies in boars have shown that certain amino acid patterns in feed may improve various semen parameters 2, 3, 4.
However, these findings cannot be directly extrapolated to humans, as the reproductive physiology differs significantly between species.
The limited human research available has focused on combinations of supplements rather than L-lysine alone. One study examined a combination of L-arginine, L-citrulline, roburins and Pycnogenol® on sperm quality, but not specifically on L-lysine for ejaculate volume 5.
Medical Guidelines on Male Reproductive Health
Current medical guidelines for male reproductive health and sexual function do not recommend L-lysine for increasing ejaculate volume:
The American Urological Association (AUA) and Sexual Medicine Society of North America (SMSNA) guidelines on disorders of ejaculation do not mention L-lysine as a treatment for any ejaculatory disorders 1.
Guidelines on male infertility from the AUA and American Society for Reproductive Medicine (ASRM) state: "There are no clear, reliable data to support use of the variety of supplements (vitamins, antioxidants, nutritional supplement formulations) that have been offered to men attempting conception" 1.
Potential Approaches for Ejaculatory Concerns
If concerned about ejaculate volume:
Address underlying health factors:
- Maintain healthy weight (obesity is associated with decreased ejaculate volume) 1
- Stay properly hydrated
- Consider abstinence period before desired ejaculation
Consult a healthcare provider if concerned about abnormally low ejaculate volume, as this could indicate:
- Retrograde ejaculation
- Ejaculatory duct obstruction
- Hypogonadism
- Other medical conditions requiring evaluation
Consider established treatments for specific ejaculatory disorders under medical supervision 1:
- Behavioral techniques
- Pharmacological approaches when indicated
- Combined approaches may be more effective than either modality alone
Conclusion
Based on current medical evidence, L-lysine supplementation is not recommended for increasing ejaculate volume. Men concerned about semen volume should consult with healthcare providers to identify and address any underlying medical conditions rather than pursuing unproven supplements.