Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: August 6, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Differential Diagnosis for a 90-year-old Male with Chronic Severe Sore Throat

Single Most Likely Diagnosis

  • Gastroesophageal Reflux Disease (GERD): This condition is common in the elderly and can cause chronic sore throat due to the reflux of stomach acid into the esophagus, irritating the throat.

Other Likely Diagnoses

  • Pharyngitis: Bacterial or viral infections can cause pharyngitis, which is a common cause of sore throat in all age groups, including the elderly.
  • Laryngopharyngeal Reflux (LPR): Similar to GERD, LPR involves the reflux of stomach acid, but it primarily affects the larynx and pharynx, leading to symptoms like sore throat.
  • Dental Issues: Poor dental health, which is common in the elderly, can lead to referred pain to the throat, causing a sore throat sensation.
  • Dry Mouth (Xerostomia): Decreased saliva production, often due to medications or aging, can lead to throat discomfort and soreness.

Do Not Miss Diagnoses

  • Oropharyngeal Cancer: Although less common, oropharyngeal cancer can present with a chronic sore throat and is critical to diagnose early due to its potential for significant morbidity and mortality.
  • Epiglottitis: This is a medical emergency that can cause severe sore throat, difficulty swallowing, and shortness of breath. It requires prompt diagnosis and treatment.
  • Tuberculosis (TB): TB can affect the throat and cause chronic sore throat, among other symptoms. It's crucial to consider, especially in high-risk populations or those with exposure history.

Rare Diagnoses

  • Sjögren's Syndrome: An autoimmune disorder that can cause dry mouth and throat, leading to sore throat symptoms, though it's less common in the presentation of a sole symptom of chronic sore throat.
  • Angioedema: A rare condition that can cause swelling of the throat, leading to sore throat and potentially life-threatening airway obstruction if not promptly treated.
  • Thyroiditis: Inflammation of the thyroid gland can cause throat pain and soreness, though it's an uncommon cause of chronic severe sore throat in the elderly.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.