Cefixime Dosage for a 10-Year-Old Girl Weighing 33kg
The recommended dose of cefixime for a 10-year-old girl weighing 33kg is 8 mg/kg/day, which equals 264 mg per day, administered as a single daily dose or divided into two doses of 132 mg every 12 hours. 1
Dosage Calculation Based on FDA Guidelines
According to the FDA-approved drug label for cefixime:
- The recommended pediatric dose is 8 mg/kg/day
- For a 33kg child, this calculates to:
- 33kg × 8 mg/kg = 264 mg daily
Based on the FDA dosage chart for pediatric patients:
- For a child weighing 33.1 to 40kg, the recommended daily dose is 300 mg 1
- This can be administered as:
- A single daily dose of 300 mg
- Two divided doses of 150 mg every 12 hours
Administration Options
Oral suspension options:
- Using 100 mg/5 mL concentration: 15 mL daily
- Using 200 mg/5 mL concentration: 7.5 mL daily 1
Administration timing:
- Can be given as a single daily dose
- Or divided into two doses (4 mg/kg every 12 hours) 1
Clinical Considerations
- For treatment of infections due to Streptococcus pyogenes, cefixime should be administered for at least 10 days 1
- Cefixime can be administered without regard to food 1
- For otitis media, the suspension formulation is preferred over tablets or capsules 1
Renal Considerations
- For patients with normal renal function (creatinine clearance ≥60 mL/min), the standard dose applies
- Dose adjustments are necessary for patients with impaired renal function (creatinine clearance <60 mL/min) 1
Clinical Efficacy
Cefixime has demonstrated effectiveness in pediatric patients for:
Potential Side Effects
- Most common adverse effect is diarrhea or loose stools (16% of pediatric patients) 2
- Side effects are generally mild and transient, occurring primarily in the first few days of treatment 5
- Twice-daily dosing (divided doses) may be associated with fewer gastrointestinal side effects than once-daily dosing 3