From the FDA Drug Label
Autonomic Nervous System dry mouth The following is a comprehensive list of adverse experiences reported with bisoprolol fumarate in worldwide studies, or in postmarketing experience (in italics): Central Nervous System Dizziness, unsteadiness, vertigo, syncope, headache, paresthesia, hypoesthesia, hyperesthesia, somnolence, sleep disturbances, anxiety/restlessness, decreased concentration/memory Autonomic Nervous System Dry mouth
Bisoprolol is associated with xerostomia (dryness of mouth), as it is listed under Autonomic Nervous System adverse experiences in the drug label, with an incidence of 1.5% in the 5 to 20 mg dose group and 1.3% in the 2.5 to 40 mg dose group 1.
- The incidence of dry mouth is reported as 0.7% for the placebo group and 1.3% for the bisoprolol group.
- Dry mouth is also included in the comprehensive list of adverse experiences reported with bisoprolol fumarate.
From the Research
Bisoprolol, a beta-blocker, is associated with xerostomia (dryness of mouth) as a side effect, as evidenced by the most recent and highest quality study available 2. The association between bisoprolol and xerostomia is attributed to its effects on the sympathetic nervous system, which can reduce saliva production. Some key points to consider:
- Xerostomia can be caused by various factors, including medications, and can have physical, social, and psychological consequences 3.
- Beta-blockers, such as bisoprolol, can affect salivary gland function and induce xerostomia 4, 5.
- Management strategies for xerostomia include substitution or discontinuation of medications, oral or systemic therapy with sialogogues, administration of saliva substitutes, and use of electro-stimulating devices 5.
- Patients experiencing xerostomia while taking bisoprolol can try several strategies to manage it, such as:
- Drinking plenty of water throughout the day
- Chewing sugar-free gum or sucking on sugar-free candies to stimulate saliva production
- Using alcohol-free mouthwash
- Avoiding caffeine, alcohol, and tobacco, which can worsen dry mouth If the dry mouth is severe or significantly affecting quality of life, it is essential to consult a doctor, as they may adjust the dosage or consider an alternative medication 6, 2.