How do MEIBO eye drops work?

How MEIBO Eye Drops Work for Dry Eye Disease

MEIBO eye drops (perfluorohexyloctane) work by forming a protective barrier on the tear film that stabilizes the lipid layer and inhibits tear evaporation, directly addressing the excessive evaporation that occurs in dry eye disease associated with meibomian gland dysfunction. 1

Mechanism of Action

Perfluorohexyloctane (MEIBO) is a novel treatment approach with specific properties that make it effective for dry eye:

• Unique Formulation: MEIBO is a nonaqueous, single-entity, preservative-free ophthalmic solution consisting of perfluorohexyloctane, an anhydrous semifluorinated alkane 2
• Barrier Formation: Forms a monolayer at the air-liquid interface of the tear film 1
• Evaporation Protection: Stabilizes the lipid layer of the tear film to prevent excessive tear evaporation 3
• Targeted Therapy: Specifically designed to address the pathophysiology of evaporative dry eye caused by meibomian gland dysfunction (MGD) 3

Clinical Evidence Supporting Efficacy

The FDA approval of MEIBO was based on robust clinical evidence:

• Phase III Trials: The GOBI and MOJAVE randomized clinical trials demonstrated statistically significant clinical improvements versus hypotonic saline in patients with dry eye secondary to meibomian gland dysfunction 2
• Long-term Benefits: The KALAHARI extension study showed sustained efficacy and tolerability for up to 52 weeks 1
• Symptom Relief: Significantly improves clinical signs of Meibomian gland disease and associated mild to moderate dry eye disease 4

Advantages Over Other Treatments

MEIBO offers several advantages compared to traditional dry eye treatments:

• First of Its Kind: It is the first and only FDA-approved eye drop that directly targets tear evaporation in patients with dry eye disease 3
• Addresses Root Cause: Unlike treatments that only supplement tears or reduce inflammation, MEIBO directly addresses the excessive evaporation that occurs in most patients with dry eye 3
• Preservative-Free: Contains no preservatives that could potentially irritate sensitive eyes 1

Proper Usage

For optimal results, MEIBO should be used as follows:

• Dosage: One drop in each affected eye, four times daily 1
• Duration: Clinical trials showed significant improvements after 8 weeks of consistent use 1
• Complementary Care: May be used as part of a comprehensive dry eye management plan that includes proper eyelid hygiene and addressing underlying meibomian gland dysfunction 2

Potential Limitations

While highly effective, patients should be aware of:

• Ocular Side Effects: Most adverse events in clinical trials were mild to moderate in severity 1
• Patient Selection: Most beneficial for patients with evaporative dry eye specifically related to meibomian gland dysfunction 4

MEIBO represents a significant advancement in dry eye treatment by directly targeting the excessive evaporation that is the primary cause of symptoms in many patients with dry eye disease, particularly those with meibomian gland dysfunction.