From the Research
Bone marrow inflammation is unlikely to significantly increase Cystatin C (CysC) levels, as the most recent and highest quality study suggests that cystatin C is not influenced by inflammation. Cystatin C is a protein produced by nearly all nucleated cells in the body, including those in the bone marrow. However, the study published in 2011 1 found that cystatin C levels did not change significantly during a period of marked inflammation caused by surgery, and did not correlate with the level of any of the inflammatory markers measured. This suggests that cystatin C is a reliable marker of kidney function, even in the presence of inflammation.
When considering the relationship between cystatin C and inflammation, it is essential to prioritize the most recent and highest quality study. While earlier studies, such as those published in 2007 2, 3 and 2005 4, suggested a possible association between cystatin C and inflammatory markers, the more recent study 1 provides stronger evidence that cystatin C is not influenced by inflammation. Another study published in 2012 5 found a positive and independent relationship between serum cystatin C levels and peripheral monocyte blood count, but this study does not directly address the question of whether bone marrow inflammation increases cystatin C levels.
Key points to consider:
- Cystatin C is a reliable marker of kidney function, even in the presence of inflammation.
- The most recent and highest quality study suggests that cystatin C is not influenced by inflammation.
- Earlier studies may have suggested a possible association between cystatin C and inflammatory markers, but the more recent study provides stronger evidence.
- Other inflammatory markers may be elevated in cases of bone marrow inflammation, and additional kidney function tests may be necessary to accurately assess renal status in these patients.