From the Research
There is currently no strong scientific evidence to suggest that nattokinase directly affects cystatin C levels in the body. Nattokinase is an enzyme derived from fermented soybeans (natto) that has been studied primarily for its potential fibrinolytic (clot-dissolving) and cardiovascular benefits. Cystatin C, on the other hand, is a protein used as a biomarker for kidney function, with elevated levels potentially indicating reduced kidney filtration capacity, as discussed in a study published in Kidney360 1. While nattokinase may have some anti-inflammatory properties that could theoretically benefit kidney health indirectly, no specific research has established a direct relationship between nattokinase supplementation and cystatin C levels. Some studies have explored the use of cystatin C as a biomarker for chronic kidney disease, highlighting its potential as a more accurate marker of kidney function compared to traditional biomarkers like serum creatinine 2, 3, 4. However, these studies do not provide evidence of a direct link between nattokinase and cystatin C levels. Additionally, research has shown that dietary protein intake does not significantly affect serum cystatin C levels independent of glomerular filtration rate, which further supports the idea that cystatin C is a reliable marker of kidney function 5. If you're concerned about your cystatin C levels, it would be more appropriate to focus on established kidney health strategies such as:
- Maintaining proper hydration
- Controlling blood pressure
- Managing blood sugar levels if diabetic
- Following your healthcare provider's recommendations Anyone considering nattokinase supplementation should consult with their healthcare provider first, especially if they have kidney concerns, bleeding disorders, or are taking blood-thinning medications, as nattokinase may have anticoagulant effects.